cd02199

YjgF_YER057c_UK114_like_1

CDD entry
Member databaseCDD
CDD typedomain
Short nameYjgF_YER057c_UK114_like_1
SetYjgF_YER057c_UK114_family

Description

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
[1, 3, 2, 11, 6, 8, 7, 12, 13, 9, 5, 4, 10, 14]

References

1.Oligomeric assembly and ligand binding of the members of protein family YER057c/YIL051c/YJGF. Mistiniene E, Luksa V, Sereikaite J, Naktinis V. Bioconjug. Chem. 14, 1243-52, (2003). View articlePMID: 14624641

2.Crystallization and preliminary X-ray analysis of the E. coli hypothetical protein TdcF. Burman JD, Stevenson CE, Hauton KA, Sawers G, Lawson DM. Acta Crystallogr. D Biol. Crystallogr. 59, 1076-8, (2003). View articlePMID: 12777779

3.Structure and oligomeric state of the mammalian tumour-associated antigen UK114. Deriu D, Briand C, Mistiniene E, Naktinis V, Grutter MG. Acta Crystallogr. D Biol. Crystallogr. 59, 1676-8, (2003). View articlePMID: 12925811

4.Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF. Mistiniene E, Pozdniakovaite N, Popendikyte V, Naktinis V. Int. J. Biol. Macromol. 37, 61-8, (2005). View articlePMID: 16198412

5.The potent vasodilating and guanylyl cyclase activating dinitrosyl-iron(II) complex is stored in a protein-bound form in vascular tissue and is released by thiols. Mulsch A, Mordvintcev P, Vanin AF, Busse R. FEBS Lett. 294, 252-6, (1991). View articlePMID: 1684553

6.Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family. Sinha S, Rappu P, Lange SC, Mantsala P, Zalkin H, Smith JL. Proc. Natl. Acad. Sci. U.S.A. 96, 13074-9, (1999). View articlePMID: 10557275

7.The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family. Burman JD, Stevenson CE, Sawers RG, Lawson DM. BMC Struct. Biol. 7, 30, (2007). View articlePMID: 17506874

8.Crystal structure of Homo sapiens protein hp14.5. Manjasetty BA, Delbruck H, Pham DT, Mueller U, Fieber-Erdmann M, Scheich C, Sievert V, Bussow K, Niesen FH, Weihofen W, Loll B, Saenger W, Heinemann U, Neisen FH. Proteins 54, 797-800, (2004). View articlePMID: 14997576

9.Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family. Parsons L, Bonander N, Eisenstein E, Gilson M, Kairys V, Orban J. Biochemistry 42, 80-9, (2003). View articlePMID: 12515541

10.DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone. Farkas A, Nardai G, Csermely P, Tompa P, Friedrich P. Biochem. J. 383, 165-70, (2004). PMID: 15250825

11.A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae. Kim JM, Yoshikawa H, Shirahige K. Genes Cells 6, 507-17, (2001). View articlePMID: 11442631

12.YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium. Christopherson MR, Schmitz GE, Downs DM. J. Bacteriol. 190, 3057-62, (2008). View articlePMID: 18296521

13.Crystal structure of the YjgF/YER057c/UK114 family protein from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7. Miyakawa T, Lee WC, Hatano K, Kato Y, Sawano Y, Miyazono K, Nagata K, Tanokura M. Proteins 62, 557-61, (2006). View articlePMID: 16323205

14.Identification of differentially expressed genes in yeast Saccharomyces cerevisiae cells with inactivated Mmf1p and Hmf1p, members of proteins family YERO57c/YJGF. Pozdniakovaite N, Popendikyte V. Dev. Growth Differ. 46, 545-54, (2004). View articlePMID: 15610144

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