cd02508

ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch

CDD entry
Member databaseCDD
CDD typedomain
Short nameADP_Glucose_PP
SetGlyco_tranf_GTA_type

Description

ADP-glucose pyrophosphorylase (glucose-1-phosphate adenylyltransferase) catalyzes a very important step in the biosynthesis of alpha 1,4-glucans (glycogen or starch) in bacteria and plants: synthesis of the activated glucosyl donor, ADP-glucose, from glucose-1-phosphate and ATP. ADP-glucose pyrophosphorylase is a tetrameric allosterically regulated enzyme. While a homotetramer in bacteria, in plant chloroplasts and amyloplasts, it is a heterotetramer of two different, yet evolutionary related, subunits. There are a number of conserved regions in the sequence of bacterial and plant ADP-glucose pyrophosphorylase subunits. It is a subfamily of a very diverse glycosy transferase family 2.
[6, 8, 2, 9, 1, 4, 5, 3, 10, 7]

References

1.A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities Campbell JA, Davies GJ, Bulone V V, Henrissat B. Biochem. J. 329 (Pt 3), 719, (1998). View articlePMID: 9445404

2.Synthesis of the glucosyl donor: ADPglucose pyrophosphorylase. Adv Food Nutr Res 41, 43-74, (1998). PMID: 9699262

3.Evolutionary considerations in relating oligosaccharide diversity to biological function. Gagneux P, Varki A. Glycobiology 9, 747-55, (1999). View articlePMID: 10406840

4.An evolving hierarchical family classification for glycosyltransferases. Coutinho PM, Deleury E, Davies GJ, Henrissat B. J. Mol. Biol. 328, 307-17, (2003). View articlePMID: 12691742

5.Conserved domains of glycosyltransferases. Kapitonov D, Yu RK. Glycobiology 9, 961-78, (1999). View articlePMID: 10521532

6.Crystal structure of potato tuber ADP-glucose pyrophosphorylase. Jin X, Ballicora MA, Preiss J, Geiger JH. EMBO J. 24, 694-704, (2005). View articlePMID: 15692569

7.Structure/function studies of glycosyltransferases. Breton C, Imberty A. Curr. Opin. Struct. Biol. 9, 563-71, (1999). View articlePMID: 10508766

8.All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases. Ten Hagen KG, Fritz TA, Tabak LA. Glycobiology 13, 1R-16R, (2003). PMID: 12634319

9.ADP-glucose pyrophosphorylase, a regulatory enzyme for bacterial glycogen synthesis. Ballicora MA, Iglesias AA, Preiss J. Microbiol Mol Biol Rev 67, 213-25, table of contents, (2003). PMID: 12794190

10.Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. Oriol R, Martinez-Duncker I, Chantret I, Mollicone R, Codogno P. Mol. Biol. Evol. 19, 1451-63, (2002). View articlePMID: 12200473

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