Member database | CDD |
CDD type | domain |
Short name | MIT_spastin |
Set | MIT |
Description
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be involved in microtubule dynamics. The molecular function of the MIT domain is unclear.
[3, 2, 4, 1]References
1.Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Hazan J, Fonknechten N, Mavel D, Paternotte C, Samson D, Artiguenave F, Davoine CS, Cruaud C, Durr A, Wincker P, Brottier P, Cattolico L, Barbe V, Burgunder JM, Prud'homme JF, Brice A, Fontaine B, Heilig B, Weissenbach J. Nat. Genet. 23, 296-303, (1999). View articlePMID: 10610178
2.The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia. Ciccarelli FD, Proukakis C, Patel H, Cross H, Azam S, Patton MA, Bork P, Crosby AH. Genomics 81, 437-41, (2003). View articlePMID: 12676568
External Links
Representative structure
7s7j: Structure of Human SPASTIN-IST1 complex.