cd02846

PAZ_argonaute_like

CDD entry
Member databaseCDD
CDD typedomain
Short namePAZ_argonaute_like
SetPAZ

Description

PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the Piwi and Dicer families. PAZ functions as a nucleic acid binding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overhangs in siRNAs within RISC (RNA-induced silencing) and other complexes.
[3, 1, 10, 5, 4, 9, 2, 7, 8, 11, 6]

References

1.RNAi: finding the elusive endonuclease. Lingel A, Izaurralde E. RNA 10, 1675-9, (2004). PMID: 15496518

2.The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Carmell MA, Xuan Z, Zhang MQ, Hannon GJ. Genes Dev 16, 2733-42, (2002). PMID: 12414724

3.Novel modes of protein-RNA recognition in the RNAi pathway. Lingel A, Sattler M. Curr Opin Struct Biol 15, 107-15, (2005). PMID: 15718141

4.Structure and conserved RNA binding of the PAZ domain. Yan KS, Yan S, Farooq A, Han A, Zeng L, Zhou MM. Nature 426, 468-74, (2003). View articlePMID: 14615802

5.Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Ma JB, Ye K, Patel DJ. Nature 429, 318-22, (2004). View articlePMID: 15152257

6.The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L. Nat. Struct. Biol. 10, 1026-32, (2003). View articlePMID: 14625589

7.Post-transcriptional gene silencing in plants. Vaucheret H, Beclin C, Fagard M. J Cell Sci 114, 3083-91, (2001). PMID: 11590235

8.Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain. Cerutti L, Mian N, Bateman A. Trends Biochem. Sci. 25, 481-2, (2000). View articlePMID: 11050429

9.Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Lingel A, Simon B, Izaurralde E, Sattler M. Nature 426, 465-9, (2003). View articlePMID: 14615801

10.Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Lingel A, Simon B, Izaurralde E, Sattler M. Nat. Struct. Mol. Biol. 11, 576-7, (2004). View articlePMID: 15156196

11.Crystal structure of Argonaute and its implications for RISC slicer activity. Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. Science 305, 1434-7, (2004). View articlePMID: 15284453

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.