cd02896

complement_C3_C4_C5

CDD entry
Member databaseCDD
CDD typedomain
Short namecomplement_C3_C4_C5
SetISOPREN_C2_like

Description

Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
[7, 8, 1, 3, 2, 10, 4, 5, 6, 9]

References

1.X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2. Nagar B, Jones RG, Diefenbach RJ, Isenman DE, Rini JM. Science 280, 1277-81, (1998). View articlePMID: 9596584

2.Complement C4 protein expression by rat hepatic stellate cells. Fimmel CJ, Brown KE, O'Neill R, Kladney RD. J Immunol 157, 2601-9, (1996). PMID: 8805663

3.X-ray crystal structure of the C4d fragment of human complement component C4. van den Elsen JM, Martin A, Wong V, Clemenza L, Rose DR, Isenman DE. J. Mol. Biol. 322, 1103-15, (2002). View articlePMID: 12367531

4.The phylogeny and evolution of the thioester bond-containing proteins C3, C4 and alpha 2-macroglobulin. Dodds AW, Law SK. Immunol. Rev. 166, 15-26, (1998). View articlePMID: 9914899

5.Characterization of a C3-like cDNA in a coral: phylogenetic implications. Dishaw LJ, Smith SL, Bigger CH. Immunogenetics 57, 535-48, (2005). PMID: 16041540

6.Evolution of the complement system. Nonaka M, Yoshizaki F. Mol Immunol 40, 897-902, (2004). PMID: 14698228

7.Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family. Mavroidis M, Sunyer JO, Lambris JD. J Immunol 154, 2164-74, (1995). PMID: 7532662

8.Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Lagueux M, Perrodou E, Levashina EA, Capovilla M, Hoffmann JA. Proc Natl Acad Sci U S A 97, 11427-32, (2000). PMID: 11027343

9.Primitive complement system of invertebrates. Nonaka M, Yoshizaki F. Immunol Rev 198, 203-15, (2004). PMID: 15199964

10.Structure of complement receptor (CR) 2 and CR2-C3d complexes. Hannan J, Young K, Szakonyi G, Overduin MJ, Perkins SJ, Chen X, Holers VM. Biochem Soc Trans 30, 983-9, (2002). PMID: 12440958

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