cd03086

PGM3

CDD entry
Member databaseCDD
CDD typedomain
Short namePGM3
Setphosphohexomutase

Description

PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into GlcNAc-1-phosphate as part of the UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthetic pathway. UDP-GlcNAc is an essential metabolite that serves as the biosynthetic precursor of many glycoproteins and mucopolysaccharides. AGM1 is a member of the alpha-D-phosphohexomutase superfamily, which catalyzes the intramolecular phosphoryl transfer of sugar substrates. The alpha-D-phosphohexomutases have four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
[2, 5, 7, 1, 3, 6, 4]

References

1.Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. Mio T, Yamada-Okabe T, Arisawa M, Yamada-Okabe H. Biochim. Biophys. Acta 1492, 369-76, (2000). View articlePMID: 11004509

2.Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1). Pang H, Koda Y, Soejima M, Kimura H. Ann. Hum. Genet. 66, 139-44, (2002). View articlePMID: 12174217

3.Functional diversity of the phosphoglucomutase superfamily: structural implications. Levin S, Almo SC, Satir BH. Protein Eng. 12, 737-46, (1999). View articlePMID: 10506283

4.Evolutionary trace analysis of the alpha-D-phosphohexomutase superfamily. Shackelford GS, Regni CA, Beamer LJ. Protein Sci. 13, 2130-8, (2004). View articlePMID: 15238632

5.Crystal structures of N-acetylglucosamine-phosphate mutase, a member of the alpha-D-phosphohexomutase superfamily, and its substrate and product complexes. Nishitani Y, Maruyama D, Nonaka T, Kita A, Fukami TA, Mio T, Yamada-Okabe H, Yamada-Okabe T, Miki K. J. Biol. Chem. 281, 19740-7, (2006). View articlePMID: 16651269

6.A phylogenetic approach to the identification of phosphoglucomutase genes. Whitehouse DB, Tomkins J, Lovegrove JU, Hopkinson DA, McMillan WO. Mol. Biol. Evol. 15, 456-62, (1998). View articlePMID: 9549096

7.Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Greig KT, Antonchuk J, Metcalf D, Morgan PO, Krebs DL, Zhang JG, Hacking DF, Bode L, Robb L, Kranz C, de Graaf C, Bahlo M, Nicola NA, Nutt SL, Freeze HH, Alexander WS, Hilton DJ, Kile BT. Mol. Cell. Biol. 27, 5849-59, (2007). View articlePMID: 17548465

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