cd03112

cobalamin synthesis protein CobW

CDD entry
Member databaseCDD
CDD typedomain
Short nameCobW-like
SetP-loop_NTPase

Description

The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.
[1, 2, 3]

References

1.Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases. Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB. Biochemistry 52, 1788-1801, (2013). View articlePMID: 24449932

2.Crystal structure of the Escherichia coli YjiA protein suggests a GTP-dependent regulatory function. Khil PP, Obmolova G, Teplyakov A, Howard AJ, Gilliland GL, Camerini-Otero RD. Proteins 54, 371-4, (2004). View articlePMID: 14696199

3.Classification and evolution of P-loop GTPases and related ATPases. Leipe DD, Wolf YI, Koonin EV, Aravind L. J. Mol. Biol. 317, 41-72, (2002). View articlePMID: 11916378

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