cd03401

Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

CDD entry
Member databaseCDD
CDD typedomain
Short nameSPFH_prohibitin
SetSPFH_like

Description

This model characterizes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of the SPFH (band 7) domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. These microdomains, in addition to being stable scaffolds, may also be dynamic units with their own regulatory functions. Prohibitin is a mitochondrial inner-membrane protein which may act as a chaperone for the stabilization of mitochondrial proteins. Human prohibitin forms a hetero-oligomeric complex with Bap-37 (prohibitin 2, an SPFH domain carrying homolog). This complex may protect non-assembled membrane proteins against proteolysis by the m-AAA protease. Prohibitin and Bap-37 yeast homologs have been implicated in yeast longevity and in the maintenance of mitochondrial morphology.
[1, 4, 5, 9, 7, 3, 2, 8, 10, 6]

References

1.The emerging roles of prohibitins in folliculogenesis. Chowdhury I, Garcia-Barrio M, Harp D, Thomas K, Matthews R, Thompson WE. Front Biosci (Elite Ed) 4, 690-9, (2012). View articlePMID: 22201905

2.Scaffolding microdomains and beyond: the function of reggie/flotillin proteins. Langhorst MF, Reuter A, Stuermer CA. Cell. Mol. Life Sci. 62, 2228-40, (2005). View articlePMID: 16091845

3.Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria. Steglich G, Neupert W, Langer T. Mol. Cell. Biol. 19, 3435-42, (1999). PMID: 10207067

4.The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins. Tavernarakis N, Driscoll M, Kyrpides NC. Trends Biochem. Sci. 24, 425-7, (1999). View articlePMID: 10542406

5.The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative disease. Nijtmans LG, Artal SM, Grivell LA, Coates PJ. Cell. Mol. Life Sci. 59, 143-55, (2002). View articlePMID: 11852914

6.The role and therapeutic potential of prohibitin in disease. Theiss AL, Sitaraman SV. Biochim. Biophys. Acta 1813, 1137-43, (2011). View articlePMID: 21296110

7.AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis. Langer T, Kaser M, Klanner C, Leonhard K. Biochem. Soc. Trans. 29, 431-6, (2001). View articlePMID: 11498003

8.Flotillins and the PHB domain protein family: rafts, worms and anaesthetics. Morrow IC, Parton RG. Traffic 6, 725-40, (2005). View articlePMID: 16101677

9.Yeast replicative life span--the mitochondrial connection. Jazwinski SM. FEMS Yeast Res. 5, 119-25, (2004). View articlePMID: 15489194

10.The SPFH domain-containing proteins: more than lipid raft markers. Browman DT, Hoegg MB, Robbins SM. Trends Cell Biol. 17, 394-402, (2007). View articlePMID: 17766116

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