cd03405

High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

CDD entry
Member databaseCDD
CDD typedomain
Short nameSPFH_HflC
SetSPFH_like

Description

This model characterizes proteins similar to prokaryotic HflC (High frequency of lysogenization C). Although many members of the SPFH (or band 7) superfamily are lipid raft associated, prokaryote plasma membranes lack cholesterol and are unlikely to have lipid raft domains. Individual proteins of this SPFH domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Escherichia coli HflC is an integral membrane protein which may localize to the plasma membrane. HflC associates with another SPFH superfamily member (HflK) to form an HflKC complex. HflKC interacts with FtsH in a large complex termed the FtsH holo-enzyme. FtsH is an AAA ATP-dependent protease which exerts progressive proteolysis against membrane-embedded and soluble substrate proteins. HflKC can modulate the activity of FtsH. HflKC plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection.
[2, 9, 7, 5, 3, 4, 8, 6, 1]

References

1.The periplasmic domains of Escherichia coli HflKC oligomerize through right-handed coiled-coil interactions. Briere LK, Dunn SD. Biochemistry 45, 8607-16, (2006). View articlePMID: 16834335

2.Flotillins and the PHB domain protein family: rafts, worms and anaesthetics. Morrow IC, Parton RG. Traffic 6, 725-40, (2005). View articlePMID: 16101677

3.The SPFH domain-containing proteins: more than lipid raft markers. Browman DT, Hoegg MB, Robbins SM. Trends Cell Biol. 17, 394-402, (2007). View articlePMID: 17766116

4.Scaffolding microdomains and beyond: the function of reggie/flotillin proteins. Langhorst MF, Reuter A, Stuermer CA. Cell. Mol. Life Sci. 62, 2228-40, (2005). View articlePMID: 16091845

5.FtsH--a single-chain charonin? Schumann W. FEMS Microbiol. Rev. 23, 1-11, (1999). View articlePMID: 10077851

6.Escherichia coli HflK and HflC can individually inhibit the HflB (FtsH)-mediated proteolysis of lambdaCII in vitro. Bandyopadhyay K, Parua PK, Datta AB, Parrack P. Arch. Biochem. Biophys. 501, 239-43, (2010). View articlePMID: 20599668

7.FtsH exists as an exceptionally large complex containing HflKC in the plasma membrane of Escherichia coli. Saikawa N, Akiyama Y, Ito K. J. Struct. Biol. 146, 123-9, (2004). View articlePMID: 15037243

8.Studies on Escherichia coli HflKC suggest the presence of an unidentified λ factor that influences the lysis-lysogeny switch. Bandyopadhyay K, Parua PK, Datta AB, Parrack P. BMC Microbiol. 11, 34, (2011). View articlePMID: 21324212

9.The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins. Tavernarakis N, Driscoll M, Kyrpides NC. Trends Biochem. Sci. 24, 425-7, (1999). View articlePMID: 10542406

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