cd03589

C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina

CDD entry
Member databaseCDD
CDD typedomain
Short nameCLECT_CEL-1_like
SetCLECT

Description

CLECT_CEL-1_like: C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. The CEL-1 CTLD binds three calcium ions and has a high specificity for N-acteylgalactosamine (GalNAc). CEL-1 exhibits strong cytotoxicity which is inhibited by GalNAc. This protein may play a role as a toxin defending against predation. Echinoidin is found in the coelomic fluid of the sea urchin and is specific for GalBeta1-3GalNAc. Echinoidin has a cell adhesive activity towards human cancer cells which is not mediated through the CTLD. Both CEL-1 and Echinoidin are multimeric proteins comprised of multiple dimers linked by disulfide bonds.
[13, 12, 6, 3, 8, 14, 5, 10, 11, 4, 1, 2, 7, 9]

References

1.Comparative analysis of structural properties of the C-type-lectin-like domain (CTLD). Zelensky AN, Gready JE. Proteins 52, 466-77, (2003). View articlePMID: 12866057

2.The C-type lectin-like domain superfamily. Zelensky AN, Gready JE. FEBS J. 272, 6179-217, (2005). View articlePMID: 16336259

3.Two distinct classes of carbohydrate-recognition domains in animal lectins. Drickamer K. J. Biol. Chem. 263, 9557-60, (1988). View articlePMID: 3290208

4.Cell adhesive activity of two animal lectins through different recognition mechanisms. Ozeki Y, Matsui T, Titani K. FEBS Lett. 289, 145-7, (1991). View articlePMID: 1915838

5.C-type lectin-like domains. Drickamer K. Curr. Opin. Struct. Biol. 9, 585-90, (1999). View articlePMID: 10508765

6.Collectins: collagenous C-type lectins of the innate immune defense system. Holmskov U, Malhotra R, Sim RB, Jensenius JC. Immunol. Today 15, 67-74, (1994). View articlePMID: 8155265

7.Primary structure of two-chain botrocetin, a von Willebrand factor modulator purified from the venom of Bothrops jararaca. Usami Y, Fujimura Y, Suzuki M, Ozeki Y, Nishio K, Fukui H, Titani K. Proc. Natl. Acad. Sci. U.S.A. 90, 928-32, (1993). View articlePMID: 8430107

8.Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity. Dodd RB, Drickamer K. Glycobiology 11, 71R-9R, (2001). View articlePMID: 11425795

9.Crystallization and preliminary crystallographic study of an invertebrate C-type lectin, CEL-I, from the marine invertebrate Cucumaria echinata. Hatakeyama T, Matsuo N, Aoyagi H, Sugawara H, Uchida T, Kurisu G, Kusunoki M. Acta Crystallogr. D Biol. Crystallogr. 58, 143-4, (2002). PMID: 11752793

10.Characteristic recognition of N-acetylgalactosamine by an invertebrate C-type Lectin, CEL-I, revealed by X-ray crystallographic analysis. Sugawara H, Kusunoki M, Kurisu G, Fujimoto T, Aoyagi H, Hatakeyama T. J. Biol. Chem. 279, 45219-25, (2004). View articlePMID: 15319425

11.The complete amino acid sequence of echinoidin, a lectin from the coelomic fluid of the sea urchin Anthocidaris crassispina. Homologies with mammalian and insect lectins. Giga Y, Ikai A, Takahashi K. J. Biol. Chem. 262, 6197-203, (1987). PMID: 3571253

12.Structural basis of lectin-carbohydrate recognition. Weis WI, Drickamer K. Annu. Rev. Biochem. 65, 441-73, (1996). View articlePMID: 8811186

13.Lectin-carbohydrate interactions: different folds, common recognition principles. Elgavish S, Shaanan B. Trends Biochem. Sci. 22, 462-7, (1997). View articlePMID: 9433125

14.The C-type lectin superfamily in the immune system. Weis WI, Taylor ME, Drickamer K. Immunol. Rev. 163, 19-34, (1998). View articlePMID: 9700499

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