cd03752

proteasome_alpha_type_4

CDD entry
Member databaseCDD
CDD typedomain
Short nameproteasome_alpha_type_4
SetNtn_hydrolase

Description

proteasome_alpha_type_4. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming an elongated alpha-beta-beta-alpha cylinder with a central cavity. The proteasome alpha and beta subunits are members of the N-terminal nucleophile (Ntn)-hydrolase superfamily. Their N-terminal threonine residues are exposed as a nucleophile in peptide bond hydrolysis. Mammals have 7 alpha and 7 beta proteasome subunits while archaea have one of each.
[4, 3, 2, 1]

References

1.The proteasome: structure, function, and role in the cell. Adams J. Cancer Treat. Rev. 29 Suppl 1, 3-9, (2003). View articlePMID: 12738238

2.A comprehensive view on proteasomal sequences: implications for the evolution of the proteasome. Gille C, Goede A, Schloetelburg C, Preissner R, Kloetzel PM, Gobel UB, Frommel C. J. Mol. Biol. 326, 1437-48, (2003). View articlePMID: 12595256

3.Structural comparison of Ntn-hydrolases. Oinonen C, Rouvinen J. Protein Sci. 9, 2329-37, (2000). View articlePMID: 11206054

4.The proteasome. Bochtler M, Ditzel L, Groll M, Hartmann C, Huber R. Annu Rev Biophys Biomol Struct 28, 295-317, (1999). View articlePMID: 10410804

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