Member database | CDD |
CDD type | domain |
Short name | M28_Nicastrin |
Set | Zinc_peptidase_like |
Description
References
1.Structural basis of human γ-secretase assembly. Sun L, Zhao L, Yang G, Yan C, Zhou R, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y. Proc Natl Acad Sci U S A 112, 6003-8, (2015). PMID: 25918421
2.Nicastrin is a resident lysosomal membrane protein. Bagshaw RD, Pasternak SH, Mahuran DJ, Callahan JW. Biochem. Biophys. Res. Commun. 300, 615-8, (2003). View articlePMID: 12507492
3.Crystal structure of the γ-secretase component nicastrin. Xie T, Yan C, Zhou R, Zhao Y, Sun L, Yang G, Lu P, Ma D, Shi Y. Proc Natl Acad Sci U S A 111, 13349-54, (2014). PMID: 25197054
4.Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior. Dries DR, Zhu Y, Brooks MM, Forero DA, Adachi M, Cenik B, West JM, Han YH, Yu C, Arbella J, Nordin A, Adolfsson R, Del-Favero J, Lu QR, Callaerts P, Birnbaum SG, Yu G. J Biol Chem 291, 11647-56, (2016). PMID: 27008863
5.Metalloaminopeptidases: common functional themes in disparate structural surroundings. Lowther WT, Matthews BW. Chem. Rev. 102, 4581-608, (2002). View articlePMID: 12475202
6.The Zn-peptidase superfamily: functional convergence after evolutionary divergence. Makarova KS, Grishin NV. J. Mol. Biol. 292, 11-7, (1999). View articlePMID: 10493853
7.Overexpression of nicastrin increases Abeta production. Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE. FASEB J 17, 1138-40, (2003). PMID: 12692078
8.Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Nature 407, 48-54, (2000). View articlePMID: 10993067
9.Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines. Satoh J, Kuroda Y. Neuropathology 21, 115-22, (2001). PMID: 11396676
10.An atomic structure of human γ-secretase. Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y. Nature 525, 212-7, (2015). View articlePMID: 26280335
11.Cellular functions of gamma-secretase-related proteins. Haffner C, Haass C. Neurodegener Dis 3, 284-9, (2006). PMID: 17047369
12.Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain. Fagan R, Swindells M, Overington J, Weir M. Trends Biochem. Sci. 26, 213-4, (2001). View articlePMID: 11295540
13.Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity. Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS. J Biol Chem 291, 6748-53, (2016). PMID: 26887941
14.Evolutionary families of metallopeptidases. Rawlings ND, Barrett AJ. Meth. Enzymol. 248, 183-228, (1995). View articlePMID: 7674922
15.gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B. J. Cell. Sci. 116, 1127-36, (2003). View articlePMID: 12584255
16.MEROPS: the peptidase database. Rawlings ND, Morton FR, Barrett AJ. Nucleic Acids Res. 34, D270-2, (2006). View articlePMID: 16381862
17.Nicastrin binds to membrane-tethered Notch. Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, Tandon A, Supala A, Song YQ, Rogaeva E, Milman P, Sato C, Yu C, Janus C, Lee J, Song L, Zhang L, Fraser PE, St George-Hyslop PH. Nat Cell Biol 3, 751-4, (2001). PMID: 11483961
18.Wild-type and mutated nicastrins do not display aminopeptidase M- and B-like activities. Fergani A, Yu G, St George-Hyslop P, Checler F. Biochem Biophys Res Commun 289, 678-80, (2001). PMID: 11726200