cd04150

ADP-ribosylation factor-1 (Arf1) and ADP-ribosylation factor-5 (Arf5)

CDD entry
Member databaseCDD
CDD typedomain
Short nameArf1_5_like
SetP-loop_NTPase

Description

The Arf1-Arf5-like subfamily contains Arf1, Arf2, Arf3, Arf4, Arf5, and related proteins. Arfs1-5 are soluble proteins that are crucial for assembling coat proteins during vesicle formation. Each contains an N-terminal myristoylated amphipathic helix that is folded into the protein in the GDP-bound state. GDP/GTP exchange exposes the helix, which anchors to the membrane. Following GTP hydrolysis, the helix dissociates from the membrane and folds back into the protein. A general feature of Arf1-5 signaling may be the cooperation of two Arfs at the same site. Arfs1-5 are generally considered to be interchangeable in function and location, but some specific functions have been assigned. Arf1 localizes to the early/cis-Golgi, where it is activated by GBF1 and recruits the coat protein COPI. It also localizes to the trans-Golgi network (TGN), where it is activated by BIG1/BIG2 and recruits the AP1, AP3, AP4, and GGA proteins. Humans, but not rodents and other lower eukaryotes, lack Arf2. Human Arf3 shares 96% sequence identity with Arf1 and is believed to generally function interchangeably with Arf1. Human Arf4 in the activated (GTP-bound) state has been shown to interact with the cytoplasmic domain of epidermal growth factor receptor (EGFR) and mediate the EGF-dependent activation of phospholipase D2 (PLD2), leading to activation of the activator protein 1 (AP-1) transcription factor. Arf4 has also been shown to recognize the C-terminal sorting signal of rhodopsin and regulate its incorporation into specialized post-Golgi rhodopsin transport carriers (RTCs). There is some evidence that Arf5 functions at the early-Golgi and the trans-Golgi to affect Golgi-associated alpha-adaptin homology Arf-binding proteins (GGAs).
[7, 5, 2, 15, 17, 4, 13, 8, 9, 12, 10, 11, 16, 1, 14, 3, 6]

References

1.Analysis of the small GTPase gene superfamily of Arabidopsis. Vernoud V, Horton AC, Yang Z, Nielsen E. Plant Physiol 131, 1191-208, (2003). PMID: 12644670

2.Localization and function of Arf family GTPases. Donaldson JG, Honda A. Biochem Soc Trans 33, 639-42, (2005). PMID: 16042562

3.ARF1 regulatory factors and COPI vesicle formation. Spang A. Curr Opin Cell Biol 14, 423-7, (2002). PMID: 12383792

4.Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4). Deretic D, Williams AH, Ransom N, Morel V, Hargrave PA, Arendt A. Proc Natl Acad Sci U S A 102, 3301-6, (2005). PMID: 15728366

5.Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic. Volpicelli-Daley LA, Li Y, Zhang CJ, Kahn RA. Mol Biol Cell 16, 4495-508, (2005). PMID: 16030262

6.The regulation of phospholipase D by inositol phospholipids and small GTPases. Powner DJ, Wakelam MJ. FEBS Lett 531, 62-4, (2002). PMID: 12401204

7.Membrane recruitment of effector proteins by Arf and Rab GTPases. Kawasaki M, Nakayama K, Wakatsuki S. Curr Opin Struct Biol 15, 681-9, (2005). PMID: 16289847

8.Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR. Nat. Genet. 36, 989-93, (2004). View articlePMID: 15314642

9.Membrane targeting: getting Arl to the Golgi. Graham TR. Curr. Biol. 14, R483-5, (2004). View articlePMID: 15203023

10.Regulation of Golgi structure and function by ARF-like protein 1 (Arl1). Lu L, Horstmann H, Ng C, Hong W. J Cell Sci 114, 4543-55, (2001). PMID: 11792819

11.Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1. Wu M, Lu L, Hong W, Song H. Nat. Struct. Mol. Biol. 11, 86-94, (2004). View articlePMID: 14718928

12.Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication. Pasqualato S, Renault L, Cherfils J. EMBO Rep. 3, 1035-41, (2002). View articlePMID: 12429613

13.The role of ADP-ribosylation factor and SAR1 in vesicular trafficking in plants. Memon AR. Biochim Biophys Acta 1664, 9-30, (2004). PMID: 15238254

14.Rab and ARF GTPase regulation of exocytosis. Collins RN. Mol. Membr. Biol. 20, 105-15, (2003). View articlePMID: 12851068

15.Multiple activities for Arf1 at the Golgi complex. Donaldson JG, Honda A, Weigert R. Biochim Biophys Acta 1744, 364-73, (2005). PMID: 15979507

16.Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Setty SR, Shin ME, Yoshino A, Marks MS, Burd CG. Curr. Biol. 13, 401-4, (2003). View articlePMID: 12620188

17.ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation. Kim SW, Hayashi M, Lo JF, Yang Y, Yoo JS, Lee JD. J Biol Chem 278, 2661-8, (2003). PMID: 12446727

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