Member database | CDD |
CDD type | domain |
Short name | SIS_Etherase |
Set | SIS |
Description
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.
[1, 2]References
1.Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase". Jaeger T, Arsic M, Mayer C. J. Biol. Chem. 280, 30100-6, (2005). View articlePMID: 15983044
2.MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall. Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT. J. Bacteriol. 188, 1660-2, (2006). View articlePMID: 16452451