cd05007

SIS_Etherase

CDD entry
Member databaseCDD
CDD typedomain
Short nameSIS_Etherase
SetSIS

Description

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.
[1, 2]

References

1.Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase". Jaeger T, Arsic M, Mayer C. J. Biol. Chem. 280, 30100-6, (2005). View articlePMID: 15983044

2.MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall. Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT. J. Bacteriol. 188, 1660-2, (2006). View articlePMID: 16452451

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