Member database | CDD |
CDD type | domain |
Short name | PB1_aPKC |
Set | PB1 |
Description
PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific protein-protein interaction which play roles in many critical cell processes. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants. The aPKC protein contains a type I/II PB1 domain.
[1, 2, 3]References
1.Isolation of MEK5 and differential expression of alternatively spliced forms. English JM, Vanderbilt CA, Xu S, Marcus S, Cobb MH. J. Biol. Chem. 270, 28897-902, (1995). View articlePMID: 7499418
2.Components of a new human protein kinase signal transduction pathway. Zhou G, Bao ZQ, Dixon JE. J. Biol. Chem. 270, 12665-9, (1995). View articlePMID: 7759517
3.Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains? Ponting CP. Protein Sci. 5, 2353-7, (1996). View articlePMID: 8931154
Integrated to
External Links
Representative structure
1wmh: Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha