cd06453

SufS_like

CDD entry
Member databaseCDD
CDD typedomain
Short nameSufS_like
SetAAT_I

Description

Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
[4, 5, 9, 8, 2, 3, 6, 7, 10, 1]

References

1.The manifold of vitamin B6 dependent enzymes. Schneider G, Kack H, Lindqvist Y. Structure 8, R1-6, (2000). View articlePMID: 10673430

2.Pyridoxal phosphate-dependent enzymes. John RA. Biochim. Biophys. Acta 1248, 81-96, (1995). View articlePMID: 7748903

3.The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes. Mehta PK, Christen P. Adv. Enzymol. Relat. Areas Mol. Biol. 74, 129-84, (2000). PMID: 10800595

4.Vitamin B6 enzymes participating in selenium amino acid metabolism. Soda K, Oikawa T, Esaki N. Biofactors 10, 257-62, (1999). PMID: 10609891

5.Structure of a NifS homologue: X-ray structure analysis of CsdB, an Escherichia coli counterpart of mammalian selenocysteine lyase. Fujii T, Maeda M, Mihara H, Kurihara T, Esaki N, Hata Y. Biochemistry 39, 1263-73, (2000). View articlePMID: 10684605

6.Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents. Amadasi A, Bertoldi M, Contestabile R, Bettati S, Cellini B, di Salvo ML, Borri-Voltattorni C, Bossa F, Mozzarelli A. Curr. Med. Chem. 14, 1291-324, (2007). View articlePMID: 17504214

7.Exploring the pyridoxal 5'-phosphate-dependent enzymes. Mozzarelli A, Bettati S. 6, 275-87, (2006). PMID: 17109392

8.Structure, evolution and action of vitamin B6-dependent enzymes. Jansonius JN. Curr. Opin. Struct. Biol. 8, 759-69, (1998). View articlePMID: 9914259

9.Common structural elements in the architecture of the cofactor-binding domains in unrelated families of pyridoxal phosphate-dependent enzymes. Denessiouk KA, Denesyuk AI, Lehtonen JV, Korpela T, Johnson MS. Proteins 35, 250-61, (1999). View articlePMID: 10223296

10.From cofactor to enzymes. The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes. Christen P, Mehta PK. Chem Rec 1, 436-47, (2001). View articlePMID: 11933250

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