Member database | CDD |
CDD type | domain |
Short name | PASTA_pknB |
Set | PASTA |
Description
PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis. PknB is a receptor-like transmembrane protein with an extracellular signal sensor domain (containing multiple PASTA domains) and an intracellular, eukaryotic serine/threonine kinase-like domain. The PASTA domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
[2, 5, 1, 4, 3]References
1.The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth. Fernandez P, Saint-Joanis B, Barilone N, Jackson M, Gicquel B, Cole ST, Alzari PM. J Bacteriol 188, 7778-84, (2006). PMID: 16980473
2.From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division. Fiuza M, Canova MJ, Zanella-Cleon I, Becchi M, Cozzone AJ, Mateos LM, Kremer L, Gil JA, Molle V. J Biol Chem 283, 18099-112, (2008). PMID: 18442973
3.The PASTA domain: a beta-lactam-binding domain. Yeats C, Finn RD, Bateman A. Trends Biochem. Sci. 27, 438, (2002). View articlePMID: 12217513
External Links
Representative structure
5e10: Crystal Structure of PASTA Domains 1 and 2 of Mycobacterium tuberculosis Protein Kinase B