cd06577

PASTA_pknB

CDD entry
Member databaseCDD
CDD typedomain
Short namePASTA_pknB
SetPASTA

Description

PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis. PknB is a receptor-like transmembrane protein with an extracellular signal sensor domain (containing multiple PASTA domains) and an intracellular, eukaryotic serine/threonine kinase-like domain. The PASTA domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
[2, 5, 1, 4, 3]

References

1.The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth. Fernandez P, Saint-Joanis B, Barilone N, Jackson M, Gicquel B, Cole ST, Alzari PM. J Bacteriol 188, 7778-84, (2006). PMID: 16980473

2.From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division. Fiuza M, Canova MJ, Zanella-Cleon I, Becchi M, Cozzone AJ, Mateos LM, Kremer L, Gil JA, Molle V. J Biol Chem 283, 18099-112, (2008). PMID: 18442973

3.The PASTA domain: a beta-lactam-binding domain. Yeats C, Finn RD, Bateman A. Trends Biochem. Sci. 27, 438, (2002). View articlePMID: 12217513

4.Serine threonine protein kinases of mycobacterial genus: phylogeny to function. Narayan A, Sachdeva P, Sharma K, Saini AK, Tyagi AK, Singh Y. Physiol Genomics 29, 66-75, (2007). PMID: 17148687

5.Evolution of transmembrane protein kinases implicated in coordinating remodeling of gram-positive peptidoglycan: inside versus outside. Jones G, Dyson P. J Bacteriol 188, 7470-6, (2006). PMID: 16936012

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