Member database | CDD |
CDD type | domain |
Short name | GH31_NET37 |
Set | AmyAc_family |
Description
NET37 (also known as KIAA1161) is a human lamina-associated nuclear envelope transmembrane protein. A member of the glycosyl hydrolase family 31 (GH31) , it has been shown to be required for myogenic differentiation of C2C12 cells. Related proteins are found in eukaryotes and prokaryotes. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.
[5, 3, 2, 1, 4]References
1.Function-unknown glycoside hydrolase family 31 proteins, mRNAs of which were expressed in rice ripening and germinating stages, are alpha-glucosidase and alpha-xylosidase. Nakai H, Tanizawa S, Ito T, Kamiya K, Kim YM, Yamamoto T, Matsubara K, Sakai M, Sato H, Imbe T, Okuyama M, Mori H, Sano Y, Chiba S, Kimura A. J Biochem 142, 491-500, (2007). PMID: 17875553
2.Structure of the Sulfolobus solfataricus alpha-glucosidase: implications for domain conservation and substrate recognition in GH31. Ernst HA, Lo Leggio L, Willemoes M, Leonard G, Blum P, Larsen S. J. Mol. Biol. 358, 1106-24, (2006). View articlePMID: 16580018
3.The nuclear envelope at a glance. Wilson KL, Berk JM. J Cell Sci 123, 1973-8, (2010). PMID: 20519579