cd06592

glucosidase NET37

CDD entry
Member databaseCDD
CDD typedomain
Short nameGH31_NET37
SetAmyAc_family

Description

NET37 (also known as KIAA1161) is a human lamina-associated nuclear envelope transmembrane protein. A member of the glycosyl hydrolase family 31 (GH31) , it has been shown to be required for myogenic differentiation of C2C12 cells. Related proteins are found in eukaryotes and prokaryotes. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.
[5, 3, 2, 1, 4]

References

1.Function-unknown glycoside hydrolase family 31 proteins, mRNAs of which were expressed in rice ripening and germinating stages, are alpha-glucosidase and alpha-xylosidase. Nakai H, Tanizawa S, Ito T, Kamiya K, Kim YM, Yamamoto T, Matsubara K, Sakai M, Sato H, Imbe T, Okuyama M, Mori H, Sano Y, Chiba S, Kimura A. J Biochem 142, 491-500, (2007). PMID: 17875553

2.Structure of the Sulfolobus solfataricus alpha-glucosidase: implications for domain conservation and substrate recognition in GH31. Ernst HA, Lo Leggio L, Willemoes M, Leonard G, Blum P, Larsen S. J. Mol. Biol. 358, 1106-24, (2006). View articlePMID: 16580018

3.The nuclear envelope at a glance. Wilson KL, Berk JM. J Cell Sci 123, 1973-8, (2010). PMID: 20519579

4.The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B. Nucleic Acids Res 37, D233-8, (2009). PMID: 18838391

5.NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation. Datta K, Guan T, Gerace L. J Biol Chem 284, 29666-76, (2009). PMID: 19706595

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.