cd06620

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases

CDD entry
Member databaseCDD
CDD typedomain
Short namePKc_Byr1_like
SetPKc_like

Description

PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
[2, 10, 11, 8, 3, 5, 4, 13, 14, 9, 6, 7, 1, 12]

References

1.A MAP kinase encoded by the ubc3 gene of Ustilago maydis is required for filamentous growth and full virulence. Mayorga ME, Gold SE. Mol Microbiol 34, 485-97, (1999). PMID: 10564490

2.Activation of the pheromone-responsive MAP kinase drives haploid cells to undergo ectopic meiosis with normal telomere clustering and sister chromatid segregation in fission yeast. Yamamoto TG, Chikashige Y, Ozoe F, Kawamukai M, Hiraoka Y. J Cell Sci 117, 3875-86, (2004). PMID: 15265989

3.Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase. Gotoh Y, Nishida E, Shimanuki M, Toda T, Imai Y, Yamamoto M. Mol Cell Biol 13, 6427-34, (1993). PMID: 8413241

4.Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase. Hughes DA, Ashworth A, Marshall CJ. Nature 364, 349-52, (1993). PMID: 8332194

5.A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL. Science 260, 315-9, (1993). PMID: 8385802

6.Mating and pathogenic development of the Smut fungus Ustilago maydis are regulated by one mitogen-activated protein kinase cascade. Muller P, Weinzierl G, Brachmann A, Feldbrugge M, Kahmann R. Eukaryot Cell 2, 1187-99, (2003). PMID: 14665454

7.ras2 Controls morphogenesis, pheromone response, and pathogenicity in the fungal pathogen Ustilago maydis. Lee N, Kronstad JW. Eukaryot Cell 1, 954-66, (2002). PMID: 12477796

8.The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity. Hakuno F, Hughes DA, Yamamoto M. Genes Cells 1, 303-15, (1996). View articlePMID: 9133664

9.The induction of sexual development and virulence in the smut fungus Ustilago maydis depends on Crk1, a novel MAPK protein. Garrido E, Voss U, Muller P, Castillo-Lluva S, Kahmann R, Perez-Martin J. Genes Dev 18, 3117-30, (2004). PMID: 15601825

10.Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe. Henkel J, Du H, Yang P, Qyang Y, Kansra S, Ko M, Kim HW, Marcus S. Differentiation 67, 98-106, (2001). PMID: 11683500

11.The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating. Pereira PS, Jones NC. Genes Cells 6, 789-802, (2001). PMID: 11554925

12.Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle. Banuett F, Herskowitz I. Genes Dev 8, 1367-78, (1994). PMID: 7926737

13.Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Xu HP, White M, Marcus S, Wigler M. Mol Cell Biol 14, 50-8, (1994). PMID: 8264618

14.Networking with mitogen-activated protein kinases. Pelech SL, Charest DL, Mordret GP, Siow YL, Palaty C, Campbell D, Charlton L, Samiei M, Sanghera JS. Mol Cell Biochem 127-128, 157-69, (1993). PMID: 7935348

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