cd06849

lipoyl_domain

CDD entry
Member databaseCDD
CDD typedomain
Short namelipoyl_domain
SetBiotinyl_lipoyl_domains

Description

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.
[2, 6, 3, 5, 7, 8, 4, 1]

References

1.Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1. Roche TE, Hiromasa Y, Turkan A, Gong X, Peng T, Yan X, Kasten SA, Bao H, Dong J. Eur J Biochem 270, 1050-6, (2003). PMID: 12631265

2.Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE, Hiromasa Y. Cell Mol Life Sci 64, 830-49, (2007). PMID: 17310282

3.2-Oxo acid dehydrogenase multienzyme complexes. The central role of the lipoyl domain. Berg A, de Kok A. Biol. Chem. 378, 617-34, (1997). PMID: 9278141

4.2-Oxo acid dehydrogenase complexes of multicellular organisms. Bunik VI. Eur J Biochem 270, 1035, (2003). PMID: 12631262

5.Lipoylation of acyltransferase components of 2-oxo acid dehydrogenase complexes. Quinn J. Methods Enzymol 279, 193-202, (1997). PMID: 9211271

6.The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria. de Kok A, Hengeveld AF, Martin A, Westphal AH. Biochim Biophys Acta 1385, 353-66, (1998). PMID: 9655933

7.Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes. Perham RN, Jones DD, Chauhan HJ, Howard MJ. Biochem Soc Trans 30, 47-51, (2002). PMID: 12023822

8.2-Oxo acid dehydrogenase complexes in redox regulation. Bunik VI. Eur J Biochem 270, 1036-42, (2003). PMID: 12631263

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