cd07958

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases

CDD entry
Member databaseCDD
CDD typedomain
Short nameAnticodon_Ia_Leu_BEm
SetAnticodon_Ia_like

Description

This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
[3, 6, 2, 4, 1, 5, 7]

References

1.Crystallization and preliminary crystallographic analysis of Thermus thermophilus leucyl-tRNA synthetase and its complexes with leucine and a non-hydrolysable leucyl-adenylate analogue. Yaremchuk A, Cusack S, Gudzera O, Grotli M, Tukalo M. Acta Crystallogr. D Biol. Crystallogr. 56, 667-9, (2000). View articlePMID: 10771445

2.Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase. Lincecum TL Jr, Tukalo M, Yaremchuk A, Mursinna RS, Williams AM, Sproat BS, Van Den Eynde W, Link A, Van Calenbergh S, Grotli M, Martinis SA, Cusack S. Mol. Cell 11, 951-63, (2003). View articlePMID: 12718881

3.The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation. Tukalo M, Yaremchuk A, Fukunaga R, Yokoyama S, Cusack S. Nat. Struct. Mol. Biol. 12, 923-30, (2005). View articlePMID: 16155583

4.The 2 A crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue. Cusack S, Yaremchuk A, Tukalo M. EMBO J. 19, 2351-61, (2000). View articlePMID: 10811626

5.Evolutionary basis for the coupled-domain motions in Thermus thermophilus leucyl-tRNA synthetase. Weimer KM, Shane BL, Brunetto M, Bhattacharyya S, Hati S. J Biol Chem 284, 10088-99, (2009). PMID: 19188368

6.Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase. Sohm B, Sissler M, Park H, King MP, Florentz C. J Mol Biol 339, 17-29, (2004). PMID: 15123417

7.Horizontal gene transfer in aminoacyl-tRNA synthetases including leucine-specific subtypes. Dohm JC, Vingron M, Staub E. J Mol Evol 63, 437-47, (2006). PMID: 16955236

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