cd08318

Death domain of Nuclear Matrix Protein P84

CDD entry
Member databaseCDD
CDD typedomain
Short nameDeath_NMPP84
SetDD

Description

Death domain (DD) found in the Nuclear Matrix Protein P84 (also known as HPR1 or THOC1). HPR1/p84 resides in the nuclear matrix and is part of the THO complex, also called TREX (transcription/export) complex, which functions in mRNP biogenesis at the interface between transcription and export of mRNA from the nucleus. Mice lacking THOC1 have abnormal testis development and are sterile. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
[7, 2, 11, 1, 10, 3, 5, 8, 4, 9, 6]

References

1.Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer. Yang J, Li Y, Khoury T, Alrawi S, Goodrich DW, Tan D. Ann Clin Lab Sci 38, 105-12, (2008). PMID: 18469354

2.Structural requirements for the ubiquitin-associated domain of the mRNA export factor Mex67 to bind its specific targets, the transcription elongation THO complex component Hpr1 and nucleoporin FXFG repeats. Hobeika M, Brockmann C, Gruessing F, Neuhaus D, Divita G, Stewart M, Dargemont C. J. Biol. Chem. 284, 17575-83, (2009). View articlePMID: 19401465

3.An allelic series for studying the mouse Thoc1 gene. Wang X, Li Y, Zhang X, Goodrich DW. Genesis 45, 32-7, (2007). PMID: 17211872

4.Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination. Gottipati P, Helleday T. Mutagenesis 24, 203-10, (2009). PMID: 19139058

5.Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse. Wang X, Chang Y, Li Y, Zhang X, Goodrich DW. Mol Cell Biol 26, 4362-7, (2006). PMID: 16705185

6.The death domain: a module shared by proteins with diverse cellular functions. Feinstein E, Kimchi A, Wallach D, Boldin M, Varfolomeev E. Trends Biochem. Sci. 20, 342-4, (1995). View articlePMID: 7482697

7.The THO complex as a key mRNP biogenesis factor in development and cell differentiation. Jimeno S, Aguilera A. J Biol 9, 6, (2010). PMID: 20236444

8.Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. Li Y, Wang X, Zhang X, Goodrich DW. Mol Cell Biol 25, 4023-33, (2005). PMID: 15870275

9.The death domain superfamily in intracellular signaling of apoptosis and inflammation. Park HH, Lo YC, Lin SC, Wang L, Yang JK, Wu H. Annu. Rev. Immunol. 25, 561-86, (2007). View articlePMID: 17201679

10.Cancer cells and normal cells differ in their requirements for Thoc1. Li Y, Lin AW, Zhang X, Wang Y, Wang X, Goodrich DW. Cancer Res 67, 6657-64, (2007). PMID: 17638875

11.Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse. Wang X, Chinnam M, Wang J, Wang Y, Zhang X, Marcon E, Moens P, Goodrich DW. Mol Cell Biol 29, 2794-803, (2009). PMID: 19307311

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