cd09329

The third LIM domain of actin binding LIM (abLIM) proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameLIM3_abLIM
SetLIM

Description

The third LIM domain of actin binding LIM (abLIM) proteins: Three homologous members of the abLIM protein family have been identified; abLIM-1, abLIM-2 and abLIM-3. The N-terminal of abLIM consists of four tandem repeats of LIM domains and the C-terminal of acting binding LIM protein is a villin headpiece domain, which has strong actin binding activity. The abLIM-1, which is expressed in retina, brain, and muscle tissue, has been indicated to function as a tumor suppressor. AbLIM-2 and -3, mainly expressed in muscle and neuronal tissue, bind to F-actin strongly. They may serve as a scaffold for signaling modules of the actin cytoskeleton and thereby modulate transcription. It has shown that LIM domains of abLIMs interact with STARS (striated muscle activator of Rho signaling), which directly binds actin and stimulates serum-response factor (SRF)-dependent transcription. All LIM domains are 50-60 amino acids in size and share two characteristic highly conserved zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes.
[11, 3, 2, 5, 9, 1, 8, 13, 12, 7, 6, 4, 10]

References

1.The LIM domain: a new structural motif found in zinc-finger-like proteins. Sanchez-Garcia I, Rabbitts TH. Trends Genet. 10, 315-20, (1994). View articlePMID: 7974745

2.The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein-protein interaction. Zheng Q, Zhao Y. Biol. Cell 99, 489-502, (2007). View articlePMID: 17696879

3.The LIM domain: from the cytoskeleton to the nucleus. Kadrmas JL, Beckerle MC. Nat. Rev. Mol. Cell Biol. 5, 920-31, (2004). View articlePMID: 15520811

4.[A review of the research progress on LIM protein family]. Zheng B, Wen JK, Han M. Sheng Li Ke Xue Jin Zhan 33, 305-8, (2002). PMID: 12650064

5.The LIM domain is a modular protein-binding interface. Schmeichel KL, Beckerle MC. Cell 79, 211-9, (1994). View articlePMID: 7954790

6.LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. Matthews JM, Visvader JE. EMBO Rep. 4, 1132-7, (2003). View articlePMID: 14647207

7.Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, Frank D, Kuwahara K, Bezprozvannaya S, Pipes GC, Bassel-Duby R, Richardson JA, Katus HA, Olson EN, Frey N. J. Biol. Chem. 282, 8393-403, (2007). View articlePMID: 17194709

8.Multistate folding of the villin headpiece domain. Tang Y, Grey MJ, McKnight J, Palmer AG 3rd, Raleigh DP. J Mol Biol 355, 1066-77, (2006). PMID: 16337228

9.Molecular dissection of a LIM domain. Schmeichel KL, Beckerle MC. Mol. Biol. Cell 8, 219-30, (1997). View articlePMID: 9190203

10.LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Dawid IB, Breen JJ, Toyama R. Trends Genet. 14, 156-62, (1998). View articlePMID: 9594664

11.LIM domain proteins. Dawid IB, Toyama R, Taira M. C. R. Acad. Sci. III, Sci. Vie 318, 295-306, (1995). PMID: 7788499

12.Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. Roof DJ, Hayes A, Adamian M, Chishti AH, Li T. J. Cell Biol. 138, 575-88, (1997). View articlePMID: 9245787

13.LIM proteins: association with the actin cytoskeleton. Khurana T, Khurana B, Noegel AA. Protoplasma 219, 1-12, (2002). PMID: 11926060

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