Member database | CDD |
CDD type | domain |
Short name | SAM_CNK1_2_3-suppressor |
Set | SAM_superfamily |
Description
References
1.A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Douziech M, Sahmi M, Laberge G, Therrien M. Genes Dev. 20, 807-19, (2006). View articlePMID: 16600912
2.The many faces of SAM. Qiao F, Bowie JU. Sci. STKE 2005, re7, (2005). View articlePMID: 15928333
3.Identifying polymer-forming SAM domains. Meruelo AD, Bowie JU. Proteins 74, 1-5, (2009). View articlePMID: 18831011
4.CNK, a RAF-binding multidomain protein required for RAS signaling. Therrien M, Wong AM, Rubin GM. Cell 95, 343-53, (1998). PMID: 9814705
5.The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Roignant JY, Hamel S, Janody F, Treisman JE. Genes Dev. 20, 795-806, (2006). View articlePMID: 16600911
6.Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. Lanigan TM, Liu A, Huang YZ, Mei L, Margolis B, Guan KL. FASEB J. 17, 2048-60, (2003). View articlePMID: 14597674
7.Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Jaffe AB, Aspenstrom P, Hall A. Mol Cell Biol 24, 1736-46, (2004). PMID: 14749388
8.CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F. Proc. Natl. Acad. Sci. U.S.A. 105, 2836-41, (2008). View articlePMID: 18287031