cd09511

SAM domain of CNK1,2,3-suppressor subfamily

CDD entry
Member databaseCDD
CDD typedomain
Short nameSAM_CNK1_2_3-suppressor
SetSAM_superfamily

Description

SAM (sterile alpha motif) domain of CNK (connector enhancer of kinase suppressor of ras (Ksr)) subfamily is a protein-protein interaction domain. CNK proteins are multidomain scaffold proteins containing a few protein-protein interaction domains and are required for connecting Rho and Ras signaling pathways. In Drosophila, the SAM domain of CNK is known to interact with the SAM domain of the aveugle protein, forming a heterodimer. Mutation of the SAM domain in human CNK1 abolishes the ability to cooperate with the Ras effector, supporting the idea that this interaction is necessary for proper Ras signal transduction.
[2, 3, 8, 4, 6, 7, 5, 1]

References

1.A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Douziech M, Sahmi M, Laberge G, Therrien M. Genes Dev. 20, 807-19, (2006). View articlePMID: 16600912

2.The many faces of SAM. Qiao F, Bowie JU. Sci. STKE 2005, re7, (2005). View articlePMID: 15928333

3.Identifying polymer-forming SAM domains. Meruelo AD, Bowie JU. Proteins 74, 1-5, (2009). View articlePMID: 18831011

4.CNK, a RAF-binding multidomain protein required for RAS signaling. Therrien M, Wong AM, Rubin GM. Cell 95, 343-53, (1998). PMID: 9814705

5.The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Roignant JY, Hamel S, Janody F, Treisman JE. Genes Dev. 20, 795-806, (2006). View articlePMID: 16600911

6.Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. Lanigan TM, Liu A, Huang YZ, Mei L, Margolis B, Guan KL. FASEB J. 17, 2048-60, (2003). View articlePMID: 14597674

7.Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Jaffe AB, Aspenstrom P, Hall A. Mol Cell Biol 24, 1736-46, (2004). PMID: 14749388

8.CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F. Proc. Natl. Acad. Sci. U.S.A. 105, 2836-41, (2008). View articlePMID: 18287031

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