cd09520

SAM domain of BICC1 (bicaudal) subfamily

CDD entry
Member databaseCDD
CDD typedomain
Short nameSAM_BICC1
SetSAM_superfamily

Description

SAM (sterile alpha motif) domain of BICC1 (bicaudal) subfamily is a protein-protein interaction domain. Proteins of this group have N-terminal K homology RNA-binding vigilin-like repeats and a C-terminal SAM domain. BICC1 is involved in the regulation of embryonic differentiation. It plays a role in the regulation of Dvl (Dishevelled) signaling, particularly in the correct cilia orientation and nodal flow generation. In Drosophila, disruption of BICC1 can disturb the normal migration direction of the anterior follicle cell of oocytes; the specific function of SAM is to recruit whole protein to the periphery of P-bodies. In mammals, mutations in this gene are associated with polycystic kidney disease and it was suggested that the BICC1 protein can indirectly interact with ANKS6 protein (ANKS6 is also associated with polycystic kidney disease) through some protein and RNA intermediates.
[7, 5, 4, 1, 3, 6, 2]

References

1.Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow. Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB. Development 136, 3019-30, (2009). View articlePMID: 19666828

2.Loss of Bicc1 impairs tubulomorphogenesis of cultured IMCD cells by disrupting E-cadherin-based cell-cell adhesion. Fu Y, Kim I, Lian P, Li A, Zhou L, Li C, Liang D, Coffey RJ, Ma J, Zhao P, Zhan Q, Wu G. Eur J Cell Biol 89, 428-36, (2010). PMID: 20219263

3.K homology domains of the mouse polycystic kidney disease-related protein, Bicaudal-C (Bicc1), mediate RNA binding in vitro. Bouvrette DJ, Price SJ, Bryda EC. Nephron Exp Nephrol 108, e27-34, (2008). PMID: 18182784

4.The polycystic kidney disease-related proteins Bicc1 and SamCystin interact. Stagner EE, Bouvrette DJ, Cheng J, Bryda EC. Biochem. Biophys. Res. Commun. 383, 16-21, (2009). View articlePMID: 19324013

5.Identifying polymer-forming SAM domains. Meruelo AD, Bowie JU. Proteins 74, 1-5, (2009). View articlePMID: 18831011

6.The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. Tran U, Zakin L, Schweickert A, Agrawal R, Doger R, Blum M, De Robertis EM, Wessely O. Development 137, 1107-16, (2010). PMID: 20215348

7.The many faces of SAM. Qiao F, Bowie JU. Sci. STKE 2005, re7, (2005). View articlePMID: 15928333

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