cd10285

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones

CDD entry
Member databaseCDD
CDD typedomain
Short namesomatotropin_like
Setgrowth_hormone_like

Description

Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.
[2, 3, 18, 7, 16, 9, 10, 21, 5, 13, 12, 14, 8, 4, 6, 19, 15, 1, 22, 11, 20, 17]

References

1.Growth hormone, insulin-like growth factors, and the skeleton. Giustina A, Mazziotti G, Canalis E. Endocr Rev 29, 535-59, (2008). PMID: 18436706

2.Somatotropic regulation of fish growth and adiposity: growth hormone (GH) and somatolactin (SL) relationship. Company R, Astola A, Pendon C, Valdivia MM, Perez-Sanchez J. Comp Biochem Physiol C Toxicol Pharmacol 130, 435-45, (2001). PMID: 11738631

3.The expanding growth hormone/prolactin family. Wallis M. J Mol Endocrinol 9, 185-8, (1992). PMID: 1476604

4.The role of growth hormone in T-cell development and reconstitution. Welniak LA, Sun R, Murphy WJ. J Leukoc Biol 71, 381-7, (2002). PMID: 11867675

5.Neuroendocrine control of growth hormone secretion. Muller EE, Locatelli V, Cocchi D. Physiol Rev 79, 511-607, (1999). PMID: 10221989

6.Growth hormone and its disorders. Ayuk J, Sheppard MC. Postgrad Med J 82, 24-30, (2006). PMID: 16397076

7.Duplicate growth hormone genes in sheep and goat. Wallis M, Lioupis A, Wallis OC. J Mol Endocrinol 21, 1-5, (1998). PMID: 9723858

8.Regulation of human growth hormone secretion and its disorders. Kato Y, Murakami Y, Sohmiya M, Nishiki M. Intern Med 41, 7-13, (2002). PMID: 11838603

9.Growth hormone and bone. Ohlsson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC. Endocr Rev 19, 55-79, (1998). PMID: 9494780

10.Growth-hormone-receptor and cytokine-receptor-family signaling. Moutoussamy S, Kelly PA, Finidori J. Eur J Biochem 255, 1-11, (1998). PMID: 9692895

11.Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Moller N, Jorgensen JO. Endocr Rev 30, 152-77, (2009). PMID: 19240267

12.Growth hormone: a reproductive endocrine-paracrine regulator? Hull KL, Harvey S. Rev Reprod 5, 175-82, (2000). PMID: 11006167

13.The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Dorshkind K, Horseman ND. Endocr Rev 21, 292-312, (2000). PMID: 10857555

14.Growth hormone: roles in female reproduction. Hull KL, Harvey S. J Endocrinol 168, 1-23, (2001). PMID: 11139766

15.Growth hormone and aging: a challenging controversy. Bartke A. Clin Interv Aging 3, 659-65, (2008). PMID: 19281058

16.Growth hormone and prolactin--molecular and functional evolution. Forsyth IA, Wallis M. J Mammary Gland Biol Neoplasia 7, 291-312, (2002). PMID: 12751893

17.Growth hormone research and therapy. Grunfield C, Papadakis M. Science 275, 465, (1997). View articlePMID: 9019805

18.Growth hormone and placental lactogen: biology, medicine and biotechnology. Barrera-Saldana HA. Gene 211, 11-8, (1998). PMID: 9573334

19.Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin. Lengyel AM. Braz J Med Biol Res 39, 1003-11, (2006). PMID: 16906274

20.Biological effects of growth hormone on carbohydrate and lipid metabolism. Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, LeRoith D. Growth Horm IGF Res 20, 1-7, (2010). PMID: 19800274

21.Role of prolactin and growth hormone on thymus physiology. De Mello-Coelho V, Savino W, Postel-Vinay MC, Dardenne M. Dev Immunol 6, 317-23, (1998). PMID: 9814605

22.Regulation of muscle mass by growth hormone and IGF-I. Velloso CP. Br J Pharmacol 154, 557-68, (2008). PMID: 18500379

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