cd11362

Ribonuclease PH

CDD entry
Member databaseCDD
CDD typedomain
Short nameRNase_PH_bact
SetRNase_PH

Description

Ribonuclease PH (RNase PH)-like 3'-5' exoribonucleases are enzymes that catalyze the 3' to 5' processing and decay of RNA substrates. Structurally all members of this family form hexameric rings (trimers of dimers). Bacterial RNase PH forms a homohexameric ring, and removes nucleotide residues following the -CCA terminus of tRNA.
[2, 9, 5, 6, 7, 3, 4, 1, 8]

References

1.The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation. Bonneau F, Basquin J, Ebert J, Lorentzen E, Conti E. Cell 139, 547-59, (2009). PMID: 19879841

2.Degradation of ribosomal RNA during starvation: comparison to quality control during steady-state growth and a role for RNase PH. Basturea GN, Zundel MA, Deutscher MP. RNA 17, 338-45, (2011). View articlePMID: 21135037

3.Structural components and architectures of RNA exosomes. Januszyk K, Lima CD. Adv. Exp. Med. Biol. 702, 9-28, (2010). View articlePMID: 21618871

4.Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core. Lorentzen E, Conti E. Mol. Cell 20, 473-81, (2005). View articlePMID: 16285928

5.Crystal structure of the tRNA processing enzyme RNase PH from Aquifex aeolicus. Ishii R, Nureki O, Yokoyama S. J. Biol. Chem. 278, 32397-404, (2003). View articlePMID: 12746447

6.The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D. Cell 91, 457-66, (1997). View articlePMID: 9390555

7.Characterization of Escherichia coli RNase PH. Kelly KO, Deutscher MP. J. Biol. Chem. 267, 17153-8, (1992). View articlePMID: 1512253

8.Running rings around RNA: a superfamily of phosphate-dependent RNases. Symmons MF, Williams MG, Luisi BF, Jones GH, Carpousis AJ. Trends Biochem. Sci. 27, 11-8, (2002). View articlePMID: 11796219

9.Ribonuclease PH plays a major role in the exonucleolytic maturation of CCA-containing tRNA precursors in Bacillus subtilis. Wen T, Oussenko IA, Pellegrini O, Bechhofer DH, Condon C. Nucleic Acids Res. 33, 3636-43, (2005). View articlePMID: 15983136

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