cd11572

Middle domain of the SAM-dependent methyltransferase RlmI and related proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameRlmI_M_like

Description

This middle or central domain is typically found between an N-terminal PUA domain and a C-terminal SAM-dependent methyltransferase domain, such as in the Escherichia coli ribosomal RNA large subunit methyltransferase RlmI (YccW). It may be involved in binding to the RNA substrate.
[2, 1]

References

1.The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii. Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D. Protein Sci. 14, 3121-8, (2005). View articlePMID: 16260766

2.Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes. Sunita S, Tkaczuk KL, Purta E, Kasprzak JM, Douthwaite S, Bujnicki JM, Sivaraman J. J. Mol. Biol. 383, 652-66, (2008). View articlePMID: 18789337

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