cd13433

Inactivation gate of the voltage-gated sodium channel alpha subunits

CDD entry
Member databaseCDD
CDD typedomain
Short nameNa_channel_gate

Description

This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
[7, 5, 4, 6, 2, 3, 8, 1]

References

1.Convergent evolution of sodium ion selectivity in metazoan neuronal signaling. Gur Barzilai M, Reitzel AM, Kraus JE, Gordon D, Technau U, Gurevitz M, Moran Y. Cell Rep 2, 242-8, (2012). PMID: 22854023

2.Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP. Bricelj VM, Connell L, Konoki K, Macquarrie SP, Scheuer T, Catterall WA, Trainer VL. Nature 434, 763-7, (2005). PMID: 15815630

3.Gene duplications and evolution of vertebrate voltage-gated sodium channels. Novak AE, Jost MC, Lu Y, Taylor AD, Zakon HH, Ribera AB. J. Mol. Evol. 63, 208-21, (2006). View articlePMID: 16830092

4.Voltage-gated sodium channels at 60: structure, function and pathophysiology. Catterall WA. J Physiol 590, 2577-89, (2012). PMID: 22473783

5.Voltage-gated sodium channel-associated proteins and alternative mechanisms of inactivation and block. Goldfarb M. Cell Mol Life Sci 69, 1067-76, (2012). PMID: 21947499

6.Sodium channel inactivation: molecular determinants and modulation. Ulbricht W. Physiol Rev 85, 1271-301, (2005). PMID: 16183913

7.Solution structure of the sodium channel inactivation gate. Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, Klevit RE. Biochemistry 38, 855-61, (1999). View articlePMID: 9893979

8.Evolution of sodium channels predates the origin of nervous systems in animals. Liebeskind BJ, Hillis DM, Zakon HH. Proc Natl Acad Sci U S A 108, 9154-9, (2011). PMID: 21576472

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