cd13620

Substrate binding domain of glutamate or arginine ABC transporter, a member of the type 2 periplasmic binding fold protein superfamily

CDD entry
Member databaseCDD
CDD typedomain
Short namePBP2_GltS
SetPeriplasmic_Binding_Protein_Type_2

Description

This family comprises of the periplasmic-binding protein component (GltS) of an ABC transporter specific for glutamate or arginine from Lactococcus lactis, as well as its closely related proteins. The GltS domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis
[5, 6, 4, 2, 3, 1]

References

1.Periplasmic binding proteins: a versatile superfamily for protein engineering. Dwyer MA, Hellinga HW. Curr. Opin. Struct. Biol. 14, 495-504, (2004). View articlePMID: 15313245

2.Domain dislocation: a change of core structure in periplasmic binding proteins in their evolutionary history. Fukami-Kobayashi K, Tateno Y, Nishikawa K. J. Mol. Biol. 286, 279-90, (1999). View articlePMID: 9931266

3.Amino acid recognition by Venus flytrap domains is encoded in an 8-residue motif. Acher FC, Bertrand HO. Biopolymers 80, 357-66, (2005). View articlePMID: 15810013

4.The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors. Felder CB, Graul RC, Lee AY, Merkle HP, Sadee W. AAPS PharmSci 1, E2, (1999). PMID: 11741199

5.Five Listeria monocytogenes genes preferentially expressed in infected mammalian cells: plcA, purH, purD, pyrE and an arginine ABC transporter gene, arpJ. Klarsfeld AD, Goossens PL, Cossart P. Mol Microbiol 13, 585-97, (1994). PMID: 7997171

6.Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Tam R, Saier MH Jr. Microbiol. Rev. 57, 320-46, (1993). View articlePMID: 8336670

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