Member database | CDD |
CDD type | domain |
Short name | PKc_DYRK1 |
Set | PKc_like |
Description
References
1.The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications. Hammerle B, Elizalde C, Galceran J, Becker W, Tejedor FJ. J Neural Transm Suppl 129-37, (2003). PMID: 15068245
2.Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. Mao J, Maye P, Kogerman P, Tejedor FJ, Toftgard R, Xie W, Wu G, Wu D. J Biol Chem 277, 35156-61, (2002). PMID: 12138125
3.The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernandez E, Fotaki V, Delabar JM, de la Luna S, de la Villa P, Arbones ML. Dev Cell 15, 841-53, (2008). PMID: 19081073
4.DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Lauth M, Bergstrom A, Shimokawa T, Tostar U, Jin Q, Fendrich V, Guerra C, Barbacid M, Toftgard R. Nat Struct Mol Biol 17, 718-25, (2010). PMID: 20512148
5.Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome. Park J, Yang EJ, Yoon JH, Chung KC. Mol Cell Neurosci 36, 270-9, (2007). PMID: 17720532
6.Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells. Kang JE, Choi SA, Park JB, Chung KC. J Neurosci Res 81, 62-72, (2005). PMID: 15906374
7.Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288. Zou Y, Ewton DZ, Deng X, Mercer SE, Friedman E. J Biol Chem 279, 27790-8, (2004). PMID: 15075324
8.Mirk/Dyrk1B in cancer. Friedman E. J. Cell. Biochem. 102, 274-9, (2007). View articlePMID: 17583556
9.The MNB/DYRK1A protein kinase: genetic and biochemical properties. Galceran J, de Graaf K, Tejedor FJ, Becker W. J Neural Transm Suppl 139-48, (2003). PMID: 15068246
10.DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Kurabayashi N, Hirota T, Sakai M, Sanada K, Fukada Y. Mol. Cell. Biol. 30, 1757-68, (2010). View articlePMID: 20123978
11.Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas. Mercer SE, Ewton DZ, Shah S, Naqvi A, Friedman E. Cancer Res 66, 5143-50, (2006). PMID: 16707437
12.Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis. Lee Y, Ha J, Kim HJ, Kim YS, Chang EJ, Song WJ, Kim HH. J Biol Chem 284, 33343-51, (2009). PMID: 19801542
13.The zebrafish dyrk1b gene is important for endoderm formation. Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, Nissen RM. Genesis 48, 20-30, (2010). PMID: 20014342
14.The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling. Jin K, Lim S, Mercer SE, Friedman E. J Biol Chem 280, 42097-105, (2005). PMID: 16257974
15.Function and regulation of Dyrk1A: towards understanding Down syndrome. Park J, Song WJ, Chung KC. Cell. Mol. Life Sci. 66, 3235-40, (2009). View articlePMID: 19685005
16.Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival. Mercer SE, Friedman E. Cell Biochem Biophys 45, 303-15, (2006). PMID: 16845176
17.Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer's disease. Ryu YS, Park SY, Jung MS, Yoon SH, Kwen MY, Lee SY, Choi SH, Radnaabazar C, Kim MK, Kim H, Kim K, Song WJ, Chung SH. J Neurochem 115, 574-84, (2010). PMID: 20456003
18.The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer. Jin K, Park S, Ewton DZ, Friedman E. Cancer Res 67, 7247-55, (2007). PMID: 17671193
19.Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC. J Biol Chem 285, 31895-906, (2010). PMID: 20696760
20.Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. Liu F, Liang Z, Wegiel J, Hwang YW, Iqbal K, Grundke-Iqbal I, Ramakrishna N, Gong CX. FASEB J 22, 3224-33, (2008). PMID: 18509201
21.Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. Gao J, Zheng Z, Rawal B, Schell MJ, Bepler G, Haura EB. Cancer Biol Ther 8, 1671-9, (2009). PMID: 19633423
22.Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. Guimera J, Casas C, Estivill X, Pritchard M. Genomics 57, 407-18, (1999). PMID: 10329007
23.Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases. Campbell LE, Proud CG. FEBS Lett 510, 31-6, (2002). PMID: 11755526
24.Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG. J Biol Chem 273, 25893-902, (1998). PMID: 9748265
25.DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy. Kuhn C, Frank D, Will R, Jaschinski C, Frauen R, Katus HA, Frey N. J Biol Chem 284, 17320-17327, (2009). PMID: 19372220
26.DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. von Groote-Bidlingmaier F, Schmoll D, Orth HM, Joost HG, Becker W, Barthel A. Biochem Biophys Res Commun 300, 764-9, (2003). PMID: 12507516
27.Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A. Fernandez-Martinez J, Vela EM, Tora-Ponsioen M, Ocana OH, Nieto MA, Galceran J. J Cell Sci 122, 1574-83, (2009). PMID: 19383720
28.The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. Deng X, Ewton DZ, Li S, Naqvi A, Mercer SE, Landas S, Friedman E. Cancer Res 66, 4149-58, (2006). PMID: 16618736
29.DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis. Dierssen M, de Lagran MM. ScientificWorldJournal 6, 1911-22, (2006). PMID: 17205196
30.Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice. Arque G, de Lagran MM, Arbones ML, Dierssen M. Neurobiol Dis 36, 312-9, (2009). PMID: 19660545
31.Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. Park J, Oh Y, Chung KC. BMB Rep 42, 6-15, (2009). PMID: 19192387