cd14328

UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameUBA_TNK1
SetUBA_like_SF

Description

TNK1, also called CD38 negative kinase 1, is a non-receptor protein tyrosine kinase (NRPTK) that has been implicated in the regulation of apoptosis, cell growth, nuclear factor-kappaB, and Ras. It associates with phospholipase C (PLC)-gamma1 and may play a role in phospholipid signal transduction. TNK1 contains an NH2-terminal kinase, a Src Homology 3 (SH3) domain, a proline-rich (PR) region, and a C-terminal ubiquitin-association (UBA) domain.
[3, 2, 1]

References

1.Tnk1/Kos1 knockout mice develop spontaneous tumors. Hoare S, Hoare K, Reinhard MK, Lee YJ, Oh SP, May WS Jr. Cancer Res 68, 8723-32, (2008). PMID: 18974114

2.Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. Felschow DM, Civin CI, Hoehn GT. Biochem. Biophys. Res. Commun. 273, 294-301, (2000). View articlePMID: 10873601

3.Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. Hoehn GT, Stokland T, Amin S, Ramirez M, Hawkins AL, Griffin CA, Small D, Civin CI. Oncogene 12, 903-13, (1996). PMID: 8632913

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