cd14600

catalytic domain of tyrosine-protein phosphatase non-receptor type 3

CDD entry
Member databaseCDD
CDD typedomain
Short namePTPc-N3
SetPTP_DSP_cys

Description

Tyrosine-protein phosphatase non-receptor type 3 (PTPN3), also called protein-tyrosine phosphatase H1 (PTP-H1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN3 interacts with mitogen-activated protein kinase p38gamma and serves as its specific phosphatase. PTPN3 and p38gamma cooperate to promote Ras-induced oncogenesis. PTPN3 is a large modular protein containing an N-terminal FERM domain, a PDZ domain and a C-terminal catalytic PTP domain. Its PDZ domain binds with the PDZ-binding motif of p38gamma and enables efficient tyrosine dephosphorylation.
[7, 8, 3, 9, 1, 6, 2, 11, 4, 5, 10, 12]

References

1.Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation. Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, Meng TC, Chen GC. Oncogene 34, 3791-803, (2015). PMID: 25263444

2.Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing. Jung Y, Kim P, Jung Y, Keum J, Kim SN, Choi YS, Do IG, Lee J, Choi SJ, Kim S, Lee JE, Kim J, Lee S, Kim J. Genes Chromosomes Cancer 51, 590-7, (2012). PMID: 22334442

3.Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation. Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC, Wang AH. Sci Signal 7, ra98, (2014). PMID: 25314968

4.Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Muller S, Knapp S. Cell 136, 352-63, (2009). View articlePMID: 19167335

5.The Extended Family of Protein Tyrosine Phosphatases. Alonso A, Nunes-Xavier CE, Bayon Y, Pulido R. Methods Mol Biol 1447, 1-23, (2016). PMID: 27514797

6.PTPN3 mutations and HBV may exert synergistic effects in the origin of the intrahepatic cholangiocarcinoma. Cardinale V, Alvaro D. Gastroenterology 147, 719-20, (2014). PMID: 25075940

7.The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3. Parker EJ. Structure 23, 608-9, (2015). PMID: 25862931

8.Protein tyrosine phosphatase PTPN3 promotes drug resistance and stem cell-like characteristics in ovarian cancer. Li S, Cao J, Zhang W, Zhang F, Ni G, Luo Q, Wang M, Tao X, Xia H. Sci Rep 6, 36873, (2016). PMID: 27833130

9.Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Chen KE, Li MY, Chou CC, Ho MR, Chen GC, Meng TC, Wang AH. Structure 23, 653-64, (2015). PMID: 25728925

10.Protein tyrosine phosphatases: from genes, to function, to disease. Tonks NK. Nat. Rev. Mol. Cell Biol. 7, 833-46, (2006). View articlePMID: 17057753

11.Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3. Hsu EC, Lin YC, Hung CS, Huang CJ, Lee MY, Yang SC, Ting LP. J Biomed Sci 14, 731-44, (2007). PMID: 17588219

12.The extended human PTPome: a growing tyrosine phosphatase family. Alonso A, Pulido R. FEBS J 283, 1404-29, (2016). PMID: 26573778

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