cd14717

Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

CDD entry
Member databaseCDD
CDD typedomain
Short namebZIP_Maf_small
SetbZIP

Description

Maf proteins are Basic leucine zipper (bZIP) transcription factors that may participate in the activator protein-1 (AP-1) complex, which is implicated in many cell functions including proliferation, apoptosis, survival, migration, tumorigenesis, and morphogenesis, among others. Maf proteins fall into two groups: small and large. The small Mafs (MafF, MafK, and MafG) do not contain a transactivation domain but do harbor the anxillary DNA-binding domain and a C-terminal bZIP domain. They form dimers with cap'n'collar (CNC) proteins that harbor transactivation domains, and they act either as activators or repressors depending on their dimerization partner. CNC transcription factors include NFE2 (nuclear factor, erythroid-derived 2) and similar proteins NFE2L1 (NFE2-like 1), NFE2L2, and NFE2L3, as well as BACH1 and BACH2. Small Mafs play roles in stress response and detoxification pathways. They also regulate the expression of betaA-globin and other genes activated during erythropoiesis. They have been implicated in various diseases such as diabetes, neurological diseases, thrombocytopenia and cancer. Triple deletion of the three small Mafs is embryonically lethal. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.
[21, 37, 23, 20, 35, 36, 8, 18, 16, 40, 4, 27, 29, 33, 30, 41, 38, 14, 5, 28, 1, 24, 11, 9, 15, 2, 22, 17, 12, 26, 7, 13, 19, 39, 6, 10, 32, 3, 34, 25, 31]

References

1.MafB is essential for renal development and F4/80 expression in macrophages. Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, Yokomizo T, Esaki R, Kuroda E, Yoh K, Kudo T, Nagata M, Greaves DR, Engel JD, Yamamoto M, Takahashi S. Mol Cell Biol 26, 5715-27, (2006). PMID: 16847325

2.Transcription factors 1: bZIP proteins. Hurst HC. 2, 101-68, (1995). PMID: 7780801

3.Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. Iwata T, Kogame K, Toki T, Yokoyama M, Yamamoto M, Ito E. Cytogenet Cell Genet 82, 88-90, (1998). PMID: 9763667

4.Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Motohashi H, O'Connor T, Katsuoka F, Engel JD, Yamamoto M. Gene 294, 1-12, (2002). PMID: 12234662

5.Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. Gosmain Y, Avril I, Mamin A, Philippe J. J Biol Chem 282, 35024-34, (2007). PMID: 17901057

6.Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW. Mol Cell Biol 13, 5604-12, (1993). PMID: 8355703

7.The novel human gene MIP functions as a co-activator of hMafF. Ye X, Li Y, Huang Q, Yu Y, Yuan H, Wang P, Wan D, Gu J, Huo K, Li YY, Lu H. Arch. Biochem. Biophys. 449, 87-93, (2006). View articlePMID: 16549056

8.Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators? Blank V. J Mol Biol 376, 913-25, (2008). PMID: 18201722

9.Deciphering B-ZIP transcription factor interactions in vitro and in vivo. Vinson C, Acharya A, Taparowsky EJ. Biochim Biophys Acta 1759, 4-12, (2006). PMID: 16580748

10.Two new members of the maf oncogene family, mafK and mafF, encode nuclear b-Zip proteins lacking putative trans-activator domain. Fujiwara KT, Kataoka K, Nishizawa M. Oncogene 8, 2371-80, (1993). PMID: 8361754

11.Cross-species annotation of basic leucine zipper factor interactions: Insight into the evolution of closed interaction networks. Deppmann CD, Alvania RS, Taparowsky EJ. Mol Biol Evol 23, 1480-92, (2006). PMID: 16731568

12.Comprehensive identification of human bZIP interactions with coiled-coil arrays. Newman JR, Keating AE. Science 300, 2097-101, (2003). PMID: 12805554

13.Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Yamamoto M, Ogami T, Koinuma D, Kato M. J. Biol. Chem. 288, 20658-67, (2013). PMID: 23737527

14.Large Maf Transcription Factors: Cousins of AP-1 Proteins and Important Regulators of Cellular Differentiation. Yang Y, Cvekl A. Einstein J Biol Med 23, 2-11, (2007). PMID: 18159220

15.Interactions of coiled coils in transcription factors: where is the specificity? Baxevanis AD, Vinson CR. Curr Opin Genet Dev 3, 278-85, (1993). PMID: 8504253

16.Roles and regulation of transcription factor MafA in islet beta-cells. Aramata S, Han SI, Kataoka K. Endocr J 54, 659-66, (2007). PMID: 17785922

17.MafG-2 is a novel Maf protein that is expressed by stimulation of extracellular H(+). Shimokawa N, Kumaki I, Takayama K. Cell. Signal. 13, 835-9, (2001). View articlePMID: 11583919

18.Immune mechanisms of allergic airway disease: regulation by transcription factors. Yamashita M, Onodera A, Nakayama T. Crit Rev Immunol 27, 539-46, (2007). PMID: 18197799

19.Activity and expression of murine small Maf family protein MafK. Igarashi K, Itoh K, Motohashi H, Hayashi N, Matuzaki Y, Nakauchi H, Nishizawa M, Yamamoto M. J Biol Chem 270, 7615-24, (1995). PMID: 7706310

20.Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells. Kaneto H, Matsuoka TA, Katakami N, Matsuhisa M. Curr Med Chem 16, 3144-51, (2009). PMID: 19689288

21.The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives. Kannan MB, Solovieva V, Blank V. Biochim. Biophys. Acta 1823, 1841-6, (2012). View articlePMID: 22721719

22.A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities. Kataoka K, Yoshitomo-Nakagawa K, Shioda S, Nishizawa M. J Biol Chem 276, 819-26, (2001). PMID: 11036080

23.Regulation of β-cell-specific and glucose-dependent MafA expression. Vanderford NL. Islets 3, 35-7, (2011). PMID: 21278484

24.MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R. Diabetes 55, 297-304, (2006). View articlePMID: 16443760

25.Cloning of MafG homologue from the rat brain by differential display and its expression after hypercapnic stimulation. Shimokawa N, Okada J, Miura M. Mol Cell Biochem 203, 135-41, (2000). PMID: 10724342

26.MafT, a new member of the small Maf protein family in zebrafish. Takagi Y, Kobayashi M, Li L, Suzuki T, Nishikawa K, Yamamoto M. Biochem Biophys Res Commun 320, 62-9, (2004). PMID: 15207702

27.Structural basis of alternative DNA recognition by Maf transcription factors. Kurokawa H, Motohashi H, Sueno S, Kimura M, Takagawa H, Kanno Y, Yamamoto M, Tanaka T. Mol Cell Biol 29, 6232-44, (2009). PMID: 19797082

28.MafB is required for islet beta cell maturation. Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R. Proc. Natl. Acad. Sci. U.S.A. 104, 3853-8, (2007). View articlePMID: 17360442

29.The transcription factor c-Maf controls touch receptor development and function. Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C. Science 335, 1373-6, (2012). PMID: 22345400

30.Novel p.M96T variant of NRL and shRNA-based suppression and replacement of NRL mutants associated with autosomal dominant retinitis pigmentosa. Hernan I, Gamundi MJ, Borras E, Maseras M, Garcia-Sandoval B, Blanco-Kelly F, Ayuso C, Carballo M. Clin Genet 82, 446-52, (2012). PMID: 21981118

31.Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene. Dhakshinamoorthy S, Jaiswal AK. J Biol Chem 275, 40134-41, (2000). PMID: 11013233

32.Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. Toki T, Itoh J, Kitazawa J, Arai K, Hatakeyama K, Akasaka J, Igarashi K, Nomura N, Yokoyama M, Yamamoto M, Ito E. Oncogene 14, 1901-10, (1997). PMID: 9150357

33.The transcription factor c-Maf in sensory neuron development. Wende H, Lechner SG, Birchmeier C. Transcription 3, 285-9, (2012). PMID: 22889842

34.Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium. Kimura T, Ivell R, Rust W, Mizumoto Y, Ogita K, Kusui C, Matsumura Y, Azuma C, Murata Y. Biochem Biophys Res Commun 264, 86-92, (1999). PMID: 10527846

35.Role of MafA in pancreatic beta-cells. Kaneto H, Matsuoka TA, Kawashima S, Yamamoto K, Kato K, Miyatsuka T, Katakami N, Matsuhisa M. Adv Drug Deliv Rev 61, 489-96, (2009). PMID: 19393272

36.A new MAFia in cancer. Eychene A, Rocques N, Pouponnot C. Nat. Rev. Cancer 8, 683-93, (2008). View articlePMID: 19143053

37.MafA and MafB activity in pancreatic β cells. Hang Y, Stein R. Trends Endocrinol. Metab. 22, 364-73, (2011). View articlePMID: 21719305

38.Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A. Dev Biol 314, 443-56, (2008). PMID: 18199433

39.Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Kataoka K, Igarashi K, Itoh K, Fujiwara KT, Noda M, Yamamoto M, Nishizawa M. Mol Cell Biol 15, 2180-90, (1995). PMID: 7891713

40.Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes. Kataoka K. J. Biochem. 141, 775-81, (2007). View articlePMID: 17569705

41.Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation. Roger JE, Nellissery J, Kim DS, Swaroop A. J. Biol. Chem. 285, 25637-44, (2010). View articlePMID: 20551322

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