cd15630

PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)

CDD entry
Member databaseCDD
CDD typedomain
Short namePHD_BAZ2B
SetPHD_SF

Description

BAZ2B, also termed WALp4, is a bromodomain-containing protein whose biological role is still elusive. It shows high sequence similarly with BAZ2A, which is the large subunit of the SNF2h-containing chromatin-remodeling complex NoRC that induces nucleosome sliding in an ATP-and histone H4 tail-dependent fashion. BAZ2B contains a TAM (TIP5/ARBP/MBD) domain, an Apolipophorin-III like domain, a DDT domain, four AT-hooks, BAZ 1 and BAZ 2 motifs, a WAKZ (WSTF/Acf1/KIAA0314/ZK783.4) motif, a plant homeodomain (PHD) finger, and a bromodomain.
[1, 2]

References

1.A novel family of bromodomain genes. Jones MH, Hamana N, Nezu J, Shimane M. Genomics 63, 40-5, (2000). View articlePMID: 10662543

2.Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A. J Med Chem 56, 10183-7, (2013). PMID: 24304323

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