cd16162

OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameOCRE_RBM5_like
SetOCRE

Description

RBM5 is a known modulator of apoptosis. It may also act as a tumor suppressor or an RNA splicing factor; it specifically binds poly(G) RNA. RBM10, a paralog of RBM5, may play an important role in mRNA generation, processing, and degradation in several cell types. The rat homolog of human RBM10 is protein S1-1, a hypothetical RNA binding protein with poly(G) and poly(U) binding capabilities. Both RBM5 and RBM10, contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, and a G-patch/D111 domain.
[3, 19, 7, 16, 9, 4, 12, 25, 15, 24, 18, 20, 11, 13, 10, 21, 1, 2, 23, 14, 22, 5, 17, 6, 8]

References

1.A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH. Eur. J. Hum. Genet. 7, 478-86, (1999). View articlePMID: 10352938

2.RNA binding motif (RBM) proteins: a novel family of apoptosis modulators? Sutherland LC, Rintala-Maki ND, White RD, Morin CD. J. Cell. Biochem. 94, 5-24, (2005). View articlePMID: 15514923

3.OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats. Callebaut I, Mornon JP. Bioinformatics 21, 699-702, (2005). View articlePMID: 15486042

4.The conserved splicing factor SUA controls alternative splicing of the developmental regulator ABI3 in Arabidopsis. Sugliani M, Brambilla V, Clerkx EJ, Koornneef M, Soppe WJ. Plant Cell 22, 1936-46, (2010). PMID: 20525852

5.LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signals. Rintala-Maki ND, Sutherland LC. Apoptosis 9, 475-84, (2004). PMID: 15192330

6.Candidate tumour suppressor LUCA-15 can regulate multiple apoptotic pathways. Mourtada-Maarabouni M, Sutherland LC, Williams GT. Apoptosis 7, 421-32, (2002). PMID: 12207175

7.Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate. Johnston JJ, Teer JK, Cherukuri PF, Hansen NF, Loftus SK; NIH Intramural Sequencing Center (NISC), Chong K, Mullikin JC, Biesecker LG. Am J Hum Genet 86, 743-8, (2010). PMID: 20451169

8.LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis. Sutherland LC, Edwards SE, Cable HC, Poirier GG, Miller BA, Cooper CS, Williams GT. Oncogene 19, 3774-81, (2000). PMID: 10949932

9.A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. Coleman MP, Ambrose HJ, Carrel L, Nemeth AH, Willard HF, Davies KE. Genomics 31, 135-8, (1996). PMID: 8808293

10.RBM5/H37 tumor suppressor, located at the lung cancer hot spot 3p21.3, alters expression of genes involved in metastasis. Oh JJ, Taschereau EO, Koegel AK, Ginther CL, Rotow JK, Isfahani KZ, Slamon DJ. Lung Cancer 70, 253-62, (2010). PMID: 20338664

11.Death by splicing: tumor suppressor RBM5 freezes splice-site pairing. Kotlajich MV, Hertel KJ. Mol. Cell 32, 162-4, (2008). View articlePMID: 18951082

12.Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes. Mourtada-Maarabouni M, Keen J, Clark J, Cooper CS, Williams GT. Exp Cell Res 312, 1745-52, (2006). PMID: 16546166

13.p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H, Sutherland LC, Brachmann RK. Int J Cancer 128, 304-18, (2011). PMID: 20309933

14.RBM5 as a putative tumor suppressor gene for lung cancer. Sutherland LC, Wang K, Robinson AG. J Thorac Oncol 5, 294-8, (2010). PMID: 20186023

15.Expression of RBM5-related factors in primary breast tissue. Rintala-Maki ND, Goard CA, Langdon CE, Wall VE, Traulsen KE, Morin CD, Bonin M, Sutherland LC. J Cell Biochem 100, 1440-58, (2007). PMID: 17131366

16.S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity. Inoue A, Tsugawa K, Tokunaga K, Takahashi KP, Uni S, Kimura M, Nishio K, Yamamoto N, Honda K, Watanabe T, Yamane H, Tani T. Biol Cell 100, 523-35, (2008). PMID: 18315527

17.Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5. Mourtada-Maarabouni M, Sutherland LC, Meredith JM, Williams GT. Genes Cells 8, 109-19, (2003). PMID: 12581154

18.Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5. Fushimi K, Ray P, Kar A, Wang L, Sutherland LC, Wu JY. Proc. Natl. Acad. Sci. U.S.A. 105, 15708-13, (2008). View articlePMID: 18840686

19.The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms. Mueller CF, Berger A, Zimmer S, Tiyerili V, Nickenig G. Arch Biochem Biophys 488, 76-82, (2009). PMID: 19508861

20.RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Bonnal S, Martinez C, Forch P, Bachi A, Wilm M, Valcarcel J. Mol. Cell 32, 81-95, (2008). View articlePMID: 18851835

21.Targeting zinc finger domains with small molecules: solution structure and binding studies of the RanBP2-type zinc finger of RBM5. Farina B, Fattorusso R, Pellecchia M. Chembiochem 12, 2837-45, (2011). View articlePMID: 22162216

22.3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. Oh JJ, Razfar A, Delgado I, Reed RA, Malkina A, Boctor B, Slamon DJ. Cancer Res 66, 3419-27, (2006). PMID: 16585163

23.RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours. Wang K, Ubriaco G, Sutherland LC. BMC Genomics 8, 348, (2007). View articlePMID: 17908320

24.The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: research update. Maarabouni MM, Williams GT. ScientificWorldJournal 6, 1705-12, (2006). PMID: 17195868

25.The apoptosis modulator and tumour suppressor protein RBM5 is a phosphoprotein. Shu Y, Rintala-Maki ND, Wall VE, Wang K, Goard CA, Langdon CE, Sutherland LC. Cell Biochem Funct 25, 643-53, (2007). PMID: 16927403

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