cd16763

RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameRING-HC_TRIM59_C-V
SetRING_Ubox

Description

TRIM59, also known as RING finger protein 104 (RNF104) or tumor suppressor TSBF-1, is a putative E3 ubiquitin-protein ligase that functions as a novel multiple cancer biomarker for immunohistochemical detection of early tumorigenesis. It is upregulated in gastric cancer and promotes gastric carcinogenesis by interacting with and targeting the P53 tumor suppressor for its ubiquitination and degradation. It also acts as a novel accessory molecule involved in cytotoxicity of BCG-activated macrophages (BAM). Moreover, TRIM59 may serve as a multifunctional regulator for innate immune signaling pathways. It interacts with ECSIT and negatively regulates nuclear factor-kappaB (NF- kappa B) and interferon regulatory factor (IRF)-3/7-mediated signal pathways. TRIM59 belongs to the C-V subclass of the TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domain, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region. In addition, TRIM59 contains a C-terminal transmembrane domain.
[5, 6, 1, 4, 3, 2]

References

1.TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis. Khatamianfar V, Valiyeva F, Rennie PS, Lu WY, Yang BB, Bauman GS, Moussa M, Xuan JW. BMJ Open 2, e001410, (2012). PMID: 23048060

2.Characterization of the oncogenic activity of the novel TRIM59 gene in mouse cancer models. Valiyeva F, Jiang F, Elmaadawi A, Moussa M, Yee SP, Raptis L, Izawa JI, Yang BB, Greenberg NM, Wang F, Xuan JW. Mol Cancer Ther 10, 1229-40, (2011). PMID: 21593385

3.TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways. Kondo T, Watanabe M, Hatakeyama S. Biochem Biophys Res Commun 422, 501-7, (2012). PMID: 22588174

4.A novel accessory molecule Trim59 involved in cytotoxicity of BCG-activated macrophages. Zhao X, Liu Q, Du B, Li P, Cui Q, Han X, Du B, Yan D, Zhu X. Mol Cells 34, 263-70, (2012). PMID: 22949172

5.Identification and characterization of a long isoform of human IFT80, IFT80-L. Huang W, Kane JK, Li MD. Biochem Biophys Res Commun 373, 653-8, (2008). PMID: 18601909

6.TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53. Zhou Z, Ji Z, Wang Y, Li J, Cao H, Zhu HH, Gao WQ. Gastroenterology 147, 1043-54, (2014). PMID: 25046164

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