cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC

CDD entry
Member databaseCDD
CDD typedomain
Short nameHATPase_EvgS-ArcB-TorS-like
SetHATPase

Description

This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
[1, 4, 15, 14, 2, 16, 8, 9, 6, 3, 11, 10, 18, 7, 17, 13, 5, 12]

References

1.GHKL, an emergent ATPase/kinase superfamily. Dutta R, Inouye M. Trends Biochem Sci 25, 24-8, (2000). PMID: 10637609

2.pH-dependent activation of the BarA-UvrY two-component system in Escherichia coli. Mondragon V, Franco B, Jonas K, Suzuki K, Romeo T, Melefors O, Georgellis D. J Bacteriol 188, 8303-6, (2006). PMID: 16980446

3.The sensory histidine kinases TorS and EvgS tend to form clusters in Escherichia coli cells. Sommer E, Koler M, Frank V, Sourjik V, Vaknin A. PLoS ONE 8, e77708, (2013). View articlePMID: 24147062

4.Identification of UvrY as the cognate response regulator for the BarA sensor kinase in Escherichia coli. Pernestig AK, Melefors O, Georgellis D. J Biol Chem 276, 225-31, (2001). PMID: 11022030

5.Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli. Johnson MD, Bell J, Clarke K, Chandler R, Pathak P, Xia Y, Marshall RL, Weinstock GM, Loman NJ, Winn PJ, Lund PA. Mol Microbiol 93, 911-27, (2014). PMID: 24995530

6.Structural analysis of sensor domains from the TMAO-responsive histidine kinase receptor TorS. Moore JO, Hendrickson WA. Structure 17, 1195-204, (2009). View articlePMID: 19748340

7.The ArcB sensor kinase of Escherichia coli autophosphorylates by an intramolecular reaction. Pena-Sandoval GR, Georgellis D. J Bacteriol 192, 1735-9, (2010). PMID: 20097862

8.An unorthodox sensor protein (TorS) mediates the induction of the tor structural genes in response to trimethylamine N-oxide in Escherichia coli. Jourlin C, Bengrine A, Chippaux M, Mejean V. Mol. Microbiol. 20, 1297-306, (1996). View articlePMID: 8809780

9.Rapid dephosphorylation of the TorR response regulator by the TorS unorthodox sensor in Escherichia coli. Ansaldi M, Jourlin-Castelli C, Lepelletier M, Theraulaz L, Mejean V. J Bacteriol 183, 2691-5, (2001). PMID: 11274133

10.The ArcBA two-component system of Escherichia coli is regulated by the redox state of both the ubiquinone and the menaquinone pool. Bekker M, Alexeeva S, Laan W, Sawers G, Teixeira de Mattos J, Hellingwerf K. J Bacteriol 192, 746-54, (2010). PMID: 19933363

11.Kinase activity of ArcB from Escherichia coli is subject to regulation by both ubiquinone and demethylmenaquinone. Sharma P, Stagge S, Bekker M, Bettenbrock K, Hellingwerf KJ. PLoS One 8, e75412, (2013). PMID: 24116043

12.Signal transduction: Gyrating protein kinases. Stock J. Curr Biol 9, R364-7, (1999). PMID: 10339418

13.Alkali metals in addition to acidic pH activate the EvgS histidine kinase sensor in Escherichia coli. Eguchi Y, Utsumi R. J Bacteriol 196, 3140-9, (2014). PMID: 24957621

14.Genetic and functional characterization of the Escherichia coli BarA-UvrY two-component system: point mutations in the HAMP linker of the BarA sensor give a dominant-negative phenotype. Tomenius H, Pernestig AK, Mendez-Catala CF, Georgellis D, Normark S, Melefors O. J Bacteriol 187, 7317-24, (2005). PMID: 16237014

15.The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources. Pernestig AK, Georgellis D, Romeo T, Suzuki K, Tomenius H, Normark S, Melefors O. J. Bacteriol. 185, 843-53, (2003). View articlePMID: 12533459

16.Effects of the global regulator CsrA on the BarA/UvrY two-component signaling system. Camacho MI, Alvarez AF, Chavez RG, Romeo T, Merino E, Georgellis D. J Bacteriol 197, 983-91, (2015). PMID: 25535275

17.Ubiquinone and menaquinone electron carriers represent the yin and yang in the redox regulation of the ArcB sensor kinase. Alvarez AF, Rodriguez C, Georgellis D. J Bacteriol 195, 3054-61, (2013). PMID: 23645604

18.Requirement of the receiver and phosphotransfer domains of ArcB for efficient dephosphorylation of phosphorylated ArcA in vivo. Pena-Sandoval GR, Kwon O, Georgellis D. J Bacteriol 187, 3267-72, (2005). PMID: 15838055

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