cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR

CDD entry
Member databaseCDD
CDD typedomain
Short nameHATPase_EcPhoR-like
SetHATPase

Description

This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
[8, 3, 2, 5, 1, 4, 6, 7]

References

1.Topology of the PhoR protein of Escherichia coli and functional analysis of internal deletion mutants. Scholten M, Tommassen J. Mol Microbiol 8, 269-75, (1993). PMID: 8391104

2.Regulation of the phosphate regulon of Escherichia coli: properties of phoR deletion mutants and subcellular localization of PhoR protein. Yamada M, Makino K, Shinagawa H, Nakata A. Mol Gen Genet 220, 366-72, (1990). PMID: 2187152

3.Nucleotide sequence of the Pseudomonas aeruginosa phoB gene, the regulatory gene for the phosphate regulon. Anba J, Bidaud M, Vasil ML, Lazdunski A. J Bacteriol 172, 4685-9, (1990). PMID: 2115874

4.A role for the PhoBR regulatory system homologue in the Vibrio cholerae phosphate-limitation response and intestinal colonization. von Kruger WMA, Humphreys S, Ketley JM. Microbiology (Reading) 145 ( Pt 9), 2463-2475, (1999). PMID: 10517599

5.Nucleotide sequence of the phoR gene, a regulatory gene for the phosphate regulon of Escherichia coli. Makino K, Shinagawa H, Amemura M, Nakata A. J Mol Biol 192, 549-56, (1986). PMID: 3550103

6.Molecular analysis of an outer membrane protein, MopB, of Methylococcus capsulatus (Bath) and structural comparisons with proteins of the OmpA family. Fjellbirkeland A, Bemanian V, McDonald IR, Murrell JC, Jensen HB. Arch Microbiol 173, 346-51, (2000). PMID: 10896213

7.Signal transduction: Gyrating protein kinases. Stock J. Curr Biol 9, R364-7, (1999). PMID: 10339418

8.GHKL, an emergent ATPase/kinase superfamily. Dutta R, Inouye M. Trends Biochem Sci 25, 24-8, (2000). PMID: 10637609

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