cd17757

DNA replication licensing factor Mcm6

CDD entry
Member databaseCDD
CDD typedomain
Short nameMCM6
SetMCM

Description

Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
[4, 3, 1, 2]

References

1.The eukaryotic Mcm2-7 replicative helicase. Vijayraghavan S, Schwacha A. Subcell Biochem 62, 113-34, (2012). PMID: 22918583

2.Structure of the eukaryotic MCM complex at 3.8 A. Li N, Zhai Y, Zhang Y, Li W, Yang M, Lei J, Tye BK, Gao N. Nature 524, 186-91, (2015). PMID: 26222030

3.Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication. Martinez MP, Wacker AL, Bruck I, Kaplan DL. Genes (Basel) 8, E117, (2017). PMID: 28383499

4.A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. Koonin EV. Nucleic Acids Res. 21, 2541-7, (1993). View articlePMID: 8332451

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