cd17920

DEXH-box helicase domain of RecQ family proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameDEXHc_RecQ
SetDEAD-like_helicase_N

Description

The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
[10, 18, 13, 7, 4, 1, 14, 19, 17, 8, 11, 12, 15, 6, 5, 2, 16, 3, 9]

References

1.Probing the structural basis of RecQ helicase function. Vindigni A, Marino F, Gileadi O. Biophys Chem 149, 67-77, (2010). PMID: 20392558

2.Comparative structural analysis of human DEAD-box RNA helicases. Schutz P, Karlberg T, van den Berg S, Collins R, Lehtio L, Hogbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarstrom M, Moche M, Thorsell AG, Schuler H. PLoS ONE 5, (2010). PMID: 20941364

3.DEAD-box helicases as integrators of RNA, nucleotide and protein binding. Putnam AA, Jankowsky E. Biochim Biophys Acta 1829, 884-93, (2013). PMID: 23416748

4.RecQ helicases: multifunctional genome caretakers. Chu WK, Hickson ID. Nat Rev Cancer 9, 644-54, (2009). PMID: 19657341

5.From unwinding to clamping - the DEAD box RNA helicase family. Linder P, Jankowsky E. Nat. Rev. Mol. Cell Biol. 12, 505-16, (2011). View articlePMID: 21779027

6.The mechanism of ATP-dependent RNA unwinding by DEAD box proteins. Hilbert M, Karow AR, Klostermeier D. Biol Chem 390, 1237-50, (2009). PMID: 19747077

7.RecQ helicases: caretakers of the genome. Hickson ID. Nat Rev Cancer 3, 169-78, (2003). PMID: 12612652

8.DExD/H box RNA helicases: from generic motors to specific dissociation functions. Tanner NK, Linder P. Mol. Cell 8, 251-62, (2001). View articlePMID: 11545728

9.Looking back on the birth of DEAD-box RNA helicases. Linder P, Fuller-Pace FV. Biochim Biophys Acta 1829, 750-5, (2013). PMID: 23542735

10.RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells. Seki M, Otsuki M, Ishii Y, Tada S, Enomoto T. Cell Cycle 7, 2472-8, (2008). PMID: 18719387

11.RecQ Helicases: Conserved Guardians of Genomic Integrity. Larsen NB, Hickson ID. Adv Exp Med Biol 767, 161-84, (2013). PMID: 23161011

12.Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P. Trends Biochem. Sci. 24, 192-8, (1999). View articlePMID: 10322435

13.Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Bohr VA. Trends Biochem Sci 33, 609-20, (2008). PMID: 18926708

14.The RecQ DNA helicases in DNA repair. Bernstein KA, Gangloff S, Rothstein R. Annu Rev Genet 44, 393-417, (2010). PMID: 21047263

15.DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation. Fuller-Pace FV. Nucleic Acids Res. 34, 4206-15, (2006). PMID: 16935882

16.Duplex unwinding with DEAD-box proteins. Jankowsky E, Putnam A. Methods Mol Biol 587, 245-64, (2010). PMID: 20225155

17.Birth of the D-E-A-D box. Linder P, Lasko PF, Ashburner M, Leroy P, Nielsen PJ, Nishi K, Schnier J, Slonimski PP. Nature 337, 121-2, (1989). View articlePMID: 2563148

18.Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology. Monnat RJ Jr. Semin Cancer Biol 20, 329-39, (2010). PMID: 20934517

19.D-E-A-D protein family of putative RNA helicases. Schmid SR, Linder P. Mol. Microbiol. 6, 283-91, (1992). View articlePMID: 1552844

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