cd17955

DEAD-box helicase domain of DEAD box protein 49

CDD entry
Member databaseCDD
CDD typedomain
Short nameDEADc_DDX49
SetDEAD-like_helicase_N

Description

DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
[11, 1, 3, 7, 6, 4, 2, 5, 8, 9, 10]

References

1.Birth of the D-E-A-D box. Linder P, Lasko PF, Ashburner M, Leroy P, Nielsen PJ, Nishi K, Schnier J, Slonimski PP. Nature 337, 121-2, (1989). View articlePMID: 2563148

2.From unwinding to clamping - the DEAD box RNA helicase family. Linder P, Jankowsky E. Nat. Rev. Mol. Cell Biol. 12, 505-16, (2011). View articlePMID: 21779027

3.Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P. Trends Biochem. Sci. 24, 192-8, (1999). View articlePMID: 10322435

4.DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation. Fuller-Pace FV. Nucleic Acids Res. 34, 4206-15, (2006). PMID: 16935882

5.Comparative structural analysis of human DEAD-box RNA helicases. Schutz P, Karlberg T, van den Berg S, Collins R, Lehtio L, Hogbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarstrom M, Moche M, Thorsell AG, Schuler H. PLoS ONE 5, (2010). PMID: 20941364

6.The mechanism of ATP-dependent RNA unwinding by DEAD box proteins. Hilbert M, Karow AR, Klostermeier D. Biol Chem 390, 1237-50, (2009). PMID: 19747077

7.DExD/H box RNA helicases: from generic motors to specific dissociation functions. Tanner NK, Linder P. Mol. Cell 8, 251-62, (2001). View articlePMID: 11545728

8.Duplex unwinding with DEAD-box proteins. Jankowsky E, Putnam A. Methods Mol Biol 587, 245-64, (2010). PMID: 20225155

9.Looking back on the birth of DEAD-box RNA helicases. Linder P, Fuller-Pace FV. Biochim Biophys Acta 1829, 750-5, (2013). PMID: 23542735

10.DEAD-box helicases as integrators of RNA, nucleotide and protein binding. Putnam AA, Jankowsky E. Biochim Biophys Acta 1829, 884-93, (2013). PMID: 23416748

11.D-E-A-D protein family of putative RNA helicases. Schmid SR, Linder P. Mol. Microbiol. 6, 283-91, (1992). View articlePMID: 1552844

External Links
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.