cd18089

tRNA methyltransferase Trm10-like

CDD entry
Member databaseCDD
CDD typedomain
Short nameSPOUT_Trm10-like
SetSPOUT_MTase

Description

Family of tRNA methyltransferase Trm10-like proteins catalyzes the N(1) methylation of guanine at position 9 (m(1)G9) of tRNA (eukaryotes) or N(1) methylation of guanine or adenine at position 9 (m1G9/m1A9) of tRNA (archaea), which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
[2, 7, 5, 1, 6, 8, 4, 3]

References

1.Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10. Krishnamohan A, Jackman JE. Nucleic Acids Res 45, 9019-9029, (2017). PMID: 28911116

2.Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. Tkaczuk KL, Dunin-Horkawicz S, Purta E, Bujnicki JM. BMC Bioinformatics 8, 73, (2007). View articlePMID: 17338813

3.Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue. Van Laer B, Roovers M, Wauters L, Kasprzak JM, Dyzma M, Deyaert E, Kumar Singh R, Feller A, Bujnicki JM, Droogmans L, Versees W. Nucleic Acids Res 44, 940-53, (2016). PMID: 26673726

4.Transfer RNA methyltransferases with a SpoU-TrmD  (SPOUT) fold and their modified nucleosides in  tRNA. Hori H. Biomolecules 7, E23, (2017). PMID: 28264529

5.Differences in substrate selectivities of the SPOUT superfamily of methyltransferases. Toyooka T, Hori H. Nucleic Acids Symp Ser (Oxf) 445-6, (2007). PMID: 18029778

6.A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Vilardo E, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W. Nucleic Acids Res 40, 11583-93, (2012). PMID: 23042678

7.SPOUT: a class of methyltransferases that includes spoU and trmD RNA methylase superfamilies, and novel superfamilies of predicted prokaryotic RNA methylases. Anantharaman V, Koonin EV, Aravind L. J. Mol. Microbiol. Biotechnol. 4, 71-5, (2002). PMID: 11763972

8.Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing. Howard MJ, Lim WH, Fierke CA, Koutmos M. Proc. Natl. Acad. Sci. U.S.A. 109, 16149-54, (2012). View articlePMID: 22991464

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