cd18310

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameBTB_POZ_NPR_plant
SetBTB_POZ

Description

NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.
[1, 14, 12, 7, 17, 9, 8, 13, 15, 10, 2, 16, 4, 6, 3, 11, 5]

References

1.The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats. Cao H, Glazebrook J, Clarke JD, Volko S, Dong X. Cell 88, 57-63, (1997). PMID: 9019406

2.The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1. Despres C, Chubak C, Rochon A, Clark R, Bethune T, Desveaux D, Fobert PR. Plant Cell 15, 2181-91, (2003). View articlePMID: 12953119

3.Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs. Zhang Y, Cheng YT, Qu N, Zhao Q, Bi D, Li X. Plant J 48, 647-56, (2006). PMID: 17076807

4.Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins. Tada Y, Spoel SH, Pajerowska-Mukhtar K, Mou Z, Song J, Wang C, Zuo J, Dong X. Science 321, 952-6, (2008). PMID: 18635760

5.Regulatory Genes Controlling MPG1 Expression and Pathogenicity in the Rice Blast Fungus Magnaporthe grisea. Lau G, Hamer JE. Plant Cell 8, 771-781, (1996). PMID: 12239399

6.An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance. Liu G, Holub EB, Alonso JM, Ecker JR, Fobert PR. Plant J 41, 304-18, (2005). PMID: 15634206

7.Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, identified in a selective screen utilizing the SA-inducible expression of the tms2 gene. Shah J, Tsui F, Klessig DF. Mol Plant Microbe Interact 10, 69-78, (1997). PMID: 9002272

8.NIMIN-1, NIMIN-2 and NIMIN-3, members of a novel family of proteins from Arabidopsis that interact with NPR1/NIM1, a key regulator of systemic acquired resistance in plants. Weigel RR, Bauscher C, Pfitzner AJ, Pfitzner UM. Plant Mol. Biol. 46, 143-60, (2001). View articlePMID: 11442055

9.Nuclear localization of NPR1 is required for activation of PR gene expression. Kinkema M, Fan W, Dong X. Plant Cell 12, 2339-2350, (2000). PMID: 11148282

10.Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis. Johnson C, Boden E, Arias J. Plant Cell 15, 1846-58, (2003). View articlePMID: 12897257

11.NPR genes, which are negatively regulated by phytochrome action in Lemna gibba L. G-3, can also be positively regulated by abscisic acid. Williams SA, Weatherwax SC, Bray EA, Tobin EM. Plant Physiol 105, 949-54, (1994). PMID: 8058840

12.NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid. Zhou JM, Trifa Y, Silva H, Pontier D, Lam E, Shah J, Klessig DF. Mol Plant Microbe Interact 13, 191-202, (2000). PMID: 10659709

13.Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes. Mou Z, Fan W, Dong X. Cell 113, 935-44, (2003). PMID: 12837250

14.The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B. Ryals J, Weymann K, Lawton K, Friedrich L, Ellis D, Steiner HY, Johnson J, Delaney TP, Jesse T, Vos P, Uknes S. Plant Cell 9, 425-39, (1997). PMID: 9090885

15.NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. Spoel SH, Koornneef A, Claessens SM, Korzelius JP, Van Pelt JA, Mueller MJ, Buchala AJ, Metraux JP, Brown R, Kazan K, Van Loon LC, Dong X, Pieterse CM. Plant Cell 15, 760-70, (2003). PMID: 12615947

16.Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis. Gingerich DJ, Gagne JM, Salter DW, Hellmann H, Estelle M, Ma L, Vierstra RD. J. Biol. Chem. 280, 18810-21, (2005). View articlePMID: 15749712

17.The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors. Despres C, DeLong C, Glaze S, Liu E, Fobert PR. Plant Cell 12, 279-90, (2000). View articlePMID: 10662863

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