cd18808

C-terminal helicase domain of Upf1-like family helicases

CDD entry
Member databaseCDD
CDD typedomain
Short nameSF1_C_Upf1
SetDEAD-like_helicase_C

Description

The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
[3, 8, 13, 1, 4, 9, 5, 7, 2, 11, 12, 10, 6]

References

1.Birth of the D-E-A-D box. Linder P, Lasko PF, Ashburner M, Leroy P, Nielsen PJ, Nishi K, Schnier J, Slonimski PP. Nature 337, 121-2, (1989). View articlePMID: 2563148

2.From unwinding to clamping - the DEAD box RNA helicase family. Linder P, Jankowsky E. Nat. Rev. Mol. Cell Biol. 12, 505-16, (2011). View articlePMID: 21779027

3.Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family. Leonaite B, Han Z, Basquin J, Bonneau F, Libri D, Porrua O, Conti E. EMBO J 36, 1590-1604, (2017). PMID: 28408439

4.Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P. Trends Biochem. Sci. 24, 192-8, (1999). View articlePMID: 10322435

5.DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation. Fuller-Pace FV. Nucleic Acids Res. 34, 4206-15, (2006). PMID: 16935882

6.Comparative structural analysis of human DEAD-box RNA helicases. Schutz P, Karlberg T, van den Berg S, Collins R, Lehtio L, Hogbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarstrom M, Moche M, Thorsell AG, Schuler H. PLoS ONE 5, (2010). PMID: 20941364

7.The mechanism of ATP-dependent RNA unwinding by DEAD box proteins. Hilbert M, Karow AR, Klostermeier D. Biol Chem 390, 1237-50, (2009). PMID: 19747077

8.Structural and functional insights into the human Upf1 helicase core. Cheng Z, Muhlrad D, Lim MK, Parker R, Song H. EMBO J. 26, 253-64, (2007). View articlePMID: 17159905

9.DExD/H box RNA helicases: from generic motors to specific dissociation functions. Tanner NK, Linder P. Mol. Cell 8, 251-62, (2001). View articlePMID: 11545728

10.Duplex unwinding with DEAD-box proteins. Jankowsky E, Putnam A. Methods Mol Biol 587, 245-64, (2010). PMID: 20225155

11.Looking back on the birth of DEAD-box RNA helicases. Linder P, Fuller-Pace FV. Biochim Biophys Acta 1829, 750-5, (2013). PMID: 23542735

12.DEAD-box helicases as integrators of RNA, nucleotide and protein binding. Putnam AA, Jankowsky E. Biochim Biophys Acta 1829, 884-93, (2013). PMID: 23416748

13.D-E-A-D protein family of putative RNA helicases. Schmid SR, Linder P. Mol. Microbiol. 6, 283-91, (1992). View articlePMID: 1552844

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