cd19702

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar proteins

CDD entry
Member databaseCDD
CDD typedomain
Short namebHLH_TS_HEN2
SetbHLH_SF

Description

HEN-2, also termed nescient helix-loop-helix 2 (Nhlh2), or Class A basic helix-loop-helix protein 34 (bHLHa34), or nescient helix loop helix 2 (NSCL-2), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
[4, 7, 1, 3, 9, 5, 8, 2, 10, 6]

References

1.A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. Lipkowitz S, Gobel V, Varterasian ML, Nakahara K, Tchorz K, Kirsch IR. J. Biol. Chem. 267, 21065-71, (1992). PMID: 1328219

2.NeuroD1 is an upstream regulator of NSCL1. Kim WY. Biochem Biophys Res Commun 419, 27-31, (2012). PMID: 22310718

3.NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression. Kruger M, Ruschke K, Braun T. EMBO J 23, 4353-64, (2004). PMID: 15470499

4.Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity. Good DJ, Coyle CA, Fox DL. Exerc Sport Sci Rev 36, 187-92, (2008). PMID: 18815487

5.Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Good DJ, Porter FD, Mahon KA, Parlow AF, Westphal H, Kirsch IR. Nat Genet 15, 397-401, (1997). PMID: 9090387

6.HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Brown L, Espinosa R 3rd, Le Beau MM, Siciliano MJ, Baer R. Proc. Natl. Acad. Sci. U.S.A. 89, 8492-6, (1992). View articlePMID: 1528853

7.NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis. Gobel V, Lipkowitz S, Kozak CA, Kirsch IR. Cell Growth Differ 3, 143-8, (1992). PMID: 1633105

8.Expression of bHLH transcription factors NSCL1 and NSCL2 in the mouse olfactory system. Suzuki Y, Tsuruga E, Yajima T, Takeda M. Chem Senses 28, 603-8, (2003). PMID: 14578122

9.Atrophy of Muller glia and photoreceptor cells in chick retina misexpressing cNSCL2. Li CM, Yan RT, Wang SZ. Invest Ophthalmol Vis Sci 42, 3103-9, (2001). PMID: 11726609

10.Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O. DNA Res 4, 345-9, (1997). PMID: 9455484

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