cd19847

B-box-type 1 zinc finger found in transcriptional intermediary factor 1 gamma (TIF1-gamma)

CDD entry
Member databaseCDD
CDD typedomain
Short nameBbox1_TIF1g_C-VI
SetBbox_SF

Description

TIF1-gamma, also known as tripartite motif-containing 33 (TRIM33), ectodermin, RFG7, or PTC7, belongs to the C-VI subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a RING finger, Bbox1 and Bbox2, and a coiled coil region, as well as a plant homeodomain (PHD), and a bromodomain (Bromo) positioned C-terminal to the RBCC domain. The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif. TIF1-gamma is an E3-ubiquitin ligase that functions as a regulator of transforming growth factor beta (TGFbeta) signaling. It inhibits the Smad4-mediated TGFbeta response by interaction with Smad2/3 or ubiquitylation of Smad4. Moreover, TIF1-gamma is an important regulator of transcription during hematopoiesis, as well as a key actor of tumorigenesis. Like other TIF1 family members, TIF1-gamma also contains an intrinsic transcriptional silencing function. It can control erythroid cell fate by regulating transcription elongation. It can bind to the anaphase-promoting complex/cyclosome (APC/C) and promotes mitosis.
[15, 14, 1, 13, 16, 6, 5, 4, 8, 11, 10, 2, 3, 7, 9, 12]

References

1.TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Bai X, Trowbridge JJ, Riley E, Lee JA, DiBiase A, Kaartinen VM, Orkin SH, Zon LI. Dev Biol 373, 422-30, (2013). PMID: 23159334

2.Transcription intermediary factor 1gamma decreases protein expression of the transcriptional cofactor, LIM-domain-binding 1. Howard PW, Ransom DG, Maurer RA. Biochem Biophys Res Commun 396, 674-8, (2010). PMID: 20447379

3.Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S. Development 137, 2571-8, (2010). PMID: 20573697

4.Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Agricola E, Randall RA, Gaarenstroom T, Dupont S, Hill CS. Mol Cell 43, 85-96, (2011). PMID: 21726812

5.Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection. Forrester NA, Patel RN, Speiseder T, Groitl P, Sedgwick GG, Shimwell NJ, Seed RI, Catnaigh PO, McCabe CJ, Stewart GS, Dobner T, Grand RJ, Martin A, Turnell AS. J Virol 86, 3167-79, (2012). PMID: 22205733

6.Dynamic regulation of Tgf-B signaling by Tif1γ: a computational approach. Andrieux G, Fattet L, Le Borgne M, Rimokh R, Theret N. PLoS One 7, e33761, (2012). PMID: 22461896

7.TIF1gamma controls erythroid cell fate by regulating transcription elongation. Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI. Cell 142, 133-43, (2010). PMID: 20603019

8.Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells. Hesling C, Fattet L, Teyre G, Jury D, Gonzalo P, Lopez J, Vanbelle C, Morel AP, Gillet G, Mikaelian I, Rimokh R. EMBO Rep 12, 665-72, (2011). PMID: 21597466

9.Generation of mice with a conditional allele for Trim33. Kim J, Kaartinen V. Genesis 46, 329-33, (2008). PMID: 18543301

10.Adult hematopoiesis is regulated by TIF1γ, a repressor of TAL1 and PU.1 transcriptional activity. Kusy S, Gault N, Ferri F, Lewandowski D, Barroca V, Jaracz-Ros A, Losson R, Romeo PH. Cell Stem Cell 8, 412-25, (2011). PMID: 21474105

11.Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia. Aucagne R, Droin N, Paggetti J, Lagrange B, Largeot A, Hammann A, Bataille A, Martin L, Yan KP, Fenaux P, Losson R, Solary E, Bastie JN, Delva L. J Clin Invest 121, 2361-70, (2011). PMID: 21537084

12.TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de The H. Oncogene 18, 1209-17, (1999). PMID: 10022127

13.Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition. Hesling C, Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R. Development 140, 167-75, (2013). PMID: 23154409

14.Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis. Sedgwick GG, Townsend K, Martin A, Shimwell NJ, Grand RJ, Stewart GS, Nilsson J, Turnell AS. Oncogene 32, 4622-33, (2013). PMID: 23160376

15.TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling. Fattet L, Ay AS, Bonneau B, Jallades L, Mikaelian I, Treilleux I, Gillet G, Hesling C, Rimokh R. J Cell Sci 126, 3713-23, (2013). PMID: 23788427

16.Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway. Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Leon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L. Am J Pathol 180, 2214-21, (2012). PMID: 22469842

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