cd20318

FXYD domain-containing ion transport regulator 2

CDD entry
Member databaseCDD
CDD typedomain
Short nameFXYD2
SetFXYD

Description

FXYD domain-containing ion transport regulator 2 (FXYD2), also known as sodium/potassium-transporting ATPase subunit gamma, or Na(+)/K(+) ATPase subunit gamma, or sodium pump gamma chain, is the regulatory subunit of the sodium/potassium-transporting ATPase (Na,K-ATPase). Na+,K+-ATPase is a heteromeric complex consisting of a large alpha-subunit, which is responsible for ATP hydrolysis, ion transport, and CTS binding, and a beta-subunit, acting as a chaperone. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia.
[4, 5, 3, 2, 1, 6, 7, 8, 9]

References

1.FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase. Crambert G, Geering K. Sci. STKE 2003, RE1, (2003). View articlePMID: 12538882

2.FXYD proteins: new regulators of Na-K-ATPase. Geering K. Am J Physiol Renal Physiol 290, F241-50, (2006). PMID: 16403837

3.Hereditary isolated renal magnesium loss maps to chromosome 11q23. Meij IC, Saar K, van den Heuvel LP, Nuernberg G, Vollmer M, Hildebrandt F, Reis A, Monnens LA, Knoers NV. Am J Hum Genet 64, 180-8, (1999). PMID: 9915957

4.The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ, Rael E. Genomics 68, 41-56, (2000). View articlePMID: 10950925

5.Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma-subunit. Kim JW, Lee Y, Lee IA, Kang HB, Choe YK, Choe IS. Biochim Biophys Acta 1350, 133-5, (1997). PMID: 9048881

6.Role of FXYD proteins in ion transport. Garty H, Karlish SJ. Annu Rev Physiol 68, 431-59, (2006). PMID: 16460279

7.Function of FXYD proteins, regulators of Na, K-ATPase. Geering K. J Bioenerg Biomembr 37, 387-92, (2005). PMID: 16691470

8.FXYD proteins as regulators of the Na,K-ATPase in the kidney. Sweadner KJ, Arystarkhova E, Donnet C, Wetzel RK. Ann N Y Acad Sci 986, 382-7, (2003). PMID: 12763854

9.FXYD proteins: new tissue- and isoform-specific regulators of Na,K-ATPase. Geering K, Beguin P, Garty H, Karlish S, Fuzesi M, Horisberger JD, Crambert G. Ann N Y Acad Sci 986, 388-94, (2003). PMID: 12763855

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