cd20390

second Tudor domain found in AT-rich interactive domain-containing protein ARID4 family

CDD entry
Member databaseCDD
CDD typedomain
Short nameTudor_ARID4_rpt2
SetTudor_SF

Description

The family contains ARID4A and its paralog ARID4B, both of which are retinoblastoma (RB)-binding proteins that function as coactivators to enhance the androgen receptor (AR) and RB transcriptional activity, and play important roles in the AR and RB pathways to control male fertility. They also act as the leukemia and tumor suppressors involved in epigenetic regulation in leukemia and Prader-Willi/Angelman syndromes. Moreover, they associate with the mSIN3A histone deacetylase (HDAC) chromatin remodeling complex through their interaction with each other, as well as with the breast cancer associated tumor suppressor ING1 and the breast cancer metastasis suppressor BRMS1. Both ARID4A and ARID4B contain tandem Tudor domains, a PWWP domain (also known as HATH domain or RBB1NT domain), an AT-rich DNA-interacting domain (ARID, also known as BRIGHT), a chromobarrel domain, and a C-terminal R2 domain. The model corresponds to the second Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
[2, 7, 1, 12, 10, 8, 13, 4, 3, 6, 9, 11, 14, 5]

References

1.Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. Meehan WJ, Samant RS, Hopper JE, Carrozza MJ, Shevde LA, Workman JL, Eckert KA, Verderame MF, Welch DR. J Biol Chem 279, 1562-9, (2004). PMID: 14581478

2.Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D. Oncogene 8, 3149-56, (1993). PMID: 8414517

3.RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG Jr, Seto E, Branton PE. Mol Cell Biol 19, 6632-41, (1999). PMID: 10490602

4.RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE. Mol Cell Biol 21, 2918-32, (2001). PMID: 11283269

5.Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis. Winter SF, Lukes L, Walker RC, Welch DR, Hunter KW. PLoS Genet. 8, e1002735, (2012). View articlePMID: 22693453

6.RBP1 induces growth arrest by repression of E2F-dependent transcription. Lai A, Marcellus RC, Corbeil HB, Branton PE. Oncogene 18, 2091-100, (1999). PMID: 10321733

7.Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites. Otterson GA, Kratzke RA, Lin AY, Johnston PG, Kaye FJ. Oncogene 8, 949-57, (1993). PMID: 8455946

8.Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation. Monroe DG, Hawse JR, Subramaniam M, Spelsberg TC. BMC Musculoskelet Disord 11, 104, (2010). PMID: 20509905

9.RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis. Cao J, Gao T, Stanbridge EJ, Irie R. J Natl Cancer Inst 93, 1159-65, (2001). PMID: 11481388

10.Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1. Gong W, Zhou T, Mo J, Perrett S, Wang J, Feng Y. J Biol Chem 287, 8531-40, (2012). PMID: 22247551

11.Identification and characterization of three new components of the mSin3A corepressor complex. Fleischer TC, Yun UJ, Ayer DE. Mol. Cell. Biol. 23, 3456-67, (2003). View articlePMID: 12724404

12.ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways. Wu RC, Jiang M, Beaudet AL, Wu MY. Proc. Natl. Acad. Sci. U.S.A. 110, 4616-21, (2013). View articlePMID: 23487765

13.RBP1 family proteins exhibit SUMOylation-dependent transcriptional repression and induce cell growth inhibition reminiscent of senescence. Binda O, Roy JS, Branton PE. Mol Cell Biol 26, 1917-31, (2006). PMID: 16479010

14.Characterization of BRCAA1 and its novel antigen epitope identification. Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A. Cancer Epidemiol Biomarkers Prev 13, 1136-45, (2004). PMID: 15247124

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