cd20452

Tudor domain found in Drosophila melanogaster Polycomb protein PCL (dPCL)and similar proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameTudor_dPCL-like
SetTudor_SF

Description

dPCL, also called Polycomblike protein, is a Polycomb group (PcG) protein that is specifically required during the first 6 hours of embryogenesis to establish the repressed state. dPCL is a component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. Like other PCL family proteins, it consists of an N-terminal Tudor domain followed by two PHD domains, and a C-terminal MTF2 domain. PCL proteins specifically recognize tri-methylated H3K36 (H3K36me3) through their N-terminal Tudor domains.
[4, 2, 5, 1, 3]

References

1.Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein. O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS. J. Biol. Chem. 276, 43065-73, (2001). View articlePMID: 11571280

2.Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Ballare C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G, Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA, Di Croce L. Nat. Struct. Mol. Biol. 19, 1257-65, (2012). View articlePMID: 23104054

3.Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression. Lonie A, D'Andrea R, Paro R, Saint R. Development 120, 2629-36, (1994). PMID: 7956837

4.Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong Z, Allen C, Roy S, Nunez JK, Nickoloff J, Kulesza CA, Yasui A, Cote J, Kutateladze TG. Nat. Struct. Mol. Biol. 19, 1266-72, (2012). View articlePMID: 23142980

5.A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3. Tie F, Prasad-Sinha J, Birve A, Rasmuson-Lestander A, Harte PJ. Mol. Cell. Biol. 23, 3352-62, (2003). View articlePMID: 12697833

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